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[(safety)-282.4(of)-279.9(hemp)-281.7(consumed)-282.4(as)-280.2(food)-279(and)-281.6(nutritional)-280.6(sup-)]TJ
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[(plements,)-366.8(with)-361.4(a)-364.8(focus)-366.3(on)-360.9(the)-365(related)-362.7(complex)-363.4(socio-)]TJ
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[(economic)-303.5(and)-297.1(regulatory)-297.2(aspects.)]TJ
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[(Hemp)-299.7(Bioactive)-303(Compounds)]TJ
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[(The)-244.5(extensive)-244.1(research)-240.8(that)-243.8(has)-240.7(probably)-242.3(made)]TJ
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(Canna-)Tj
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(bis)Tj
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[(the)-597.8(most)-603.4(studied)-600.3(plant)-598.7(in)-600.9(human)-599.2(history)-599.1(has)]TJ
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[(allowed)-379.9(to)-372.3(identify)-376.7(hundreds)-378.1(of)-378.1(different)-375.5(compounds)]TJ
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[(120)-466.7(terpenoids,)-462.5(100)-466.7(cannabinoids,)-460.8(50)-464.6(hydrocarbons,)]TJ
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[(34)-283.6(glycosidic)-283.1(compounds,)-282.9(27)-283.6(nitrogenous)-283.1(compounds,)]TJ
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[(25)-350.8(noncannabinoid)-350.6(phenols,)-348.5(22)-345.6(fatty)-351.7(acids,)-350.9(21)-345.6(simple)]TJ
T*
[(acids,)-263(18)-262.9(amino)-259.1(acids,)-257.8(13)-262.9(simple)-259.5(ketones,)-256.3(13)-262.9(simple)-259.5(es-)]TJ
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[(ters)-225(and)-219.5(lactones,)-218.7(12)-216.3(simple)-223.3(aldehydes,)-220.7(11)-216.3(proteins,)-219(gly-)]TJ
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[(coproteins,)-270.4(and)-266.1(enzymes,)-264.8(11)-268(steroids,)-266.7(9)-265.9(trace)-263.6(elements,)]TJ
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(19)Tj
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[(Two)-350.7(recently)-349.6(published)-350.7(studies)-352.8(using)-355.7(an)-351.5(optimized)]TJ
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(sulfolipids,)Tj
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(20)Tj
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[(lic)-600.1(acids.)]TJ
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(21)Tj
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[(Nonpsychoactive)-596.6(cannabinoids)-590.8(reported)]TJ
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[(in)-321.6(hemp)-323.1(include)-320.6(the)-323.7(abovementioned)-318.3(CBD,)-317.8(as)-321.6(well)-321.1(as)]TJ
T*
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(others.)Tj
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(22)Tj
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[(binoid)-316(receptors)-316.2(\(CB1)-313.5(and)-317.8(CB2\))-313.5(and)-312.6(two)-316.1(endogenous)]TJ
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(23,24)Tj
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[(The)-384.2(endocannabinoid)-389.2(system)-382.9(is)-384.9(physiologically)-383.9(in-)]TJ
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0 Tc
[(volved)-465.7(in)-471.6(regulation)-463.1(of)-466.1(appetite,)-468.2(pain,)-465.8(mood,)-466(mem-)]TJ
T*
[(ory,)-498.2(inammation,)-494.8(insulin)-492.1(sensitivity,)-494.3(as)-497.5(well)-491.8(as)-497.5(fat)]TJ
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[(and)-328.1(energy)-326.8(metabolism,)-322.9(with)-320(a)-328.6(wide)-325.6(variety)-321(of)-326.4(poten-)]TJ
0 -1.1795 TD
[(tial)-561.6(therapeutic)-559.9(implications)-556.5(for)-557.3(treatment)-557(of)-559.2(pain,)]TJ
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[(neuropsychiatric)-371.8(disorders,)-377.9(neurologica)6.1(l)-376(diseases,)-370.9(and)]TJ
0 -1.1795 TD
[(inammatory)-298.6(bowel,)-299.8(which)-295.8(may)-300.2(benet)-294.5(from)-298.9(CB1)-299.6(ac-)]TJ
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[(benet)-299.6(from)-298.9(CB1)-299.6(antagonism.)]TJ
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(25)Tj
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(20)Tj
42.7246 0 TD
[(CERINO)-310.1(ET)-299.4(AL.)]TJ
ET
endstream
endobj
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<>stream
/GS1 gs
BT
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(26)Tj
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T*
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(l)Tj
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[(M)10.7(,)-304.5(a)12.8(s)-303.3(we)22.1(ll)]TJ
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[(weeks)-405.7(of)-404(chronic)-401.9(unpredictable)-404.4(stress,)-406.7(CBD)-401.3(repeated)]TJ
T*
[(administration)-219.9(at)-218(the)-220.2(dose)-222.7(of)-217.8(30)-164.6(mg/kg)-223.5(exerted)-217.5(a)-220(potent)]TJ
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[(anxiolytic)-365.6(effect)-366.7(through)-358.4(the)-365(CB1)-361.6(cannabinoid)-365.1(recep-)]TJ
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[(an)10.6(d)-235.3(r)0(e)9.2(v)0(e)10.1(rsa)16.5(l)-231.1(o)0(f)-228.1(C)0(B)12.9(D)-233.2(eff)15.1(ec)9.5(ts)-229(th)10.5(ro)10.4(ug)10.6(h)-229.5(a)0(d)10.3(m)0(i)11.5(n)0(i)9.5(str)10.9(at)14.8(ion)-225.1(of)-222.9(a)]TJ
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(29)Tj
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[(Interestingly,)-364.1(CBD)-359.9(spectrum)-362.5(of)-367.8(biological)-359.3(activities)]TJ
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[(includes)-463.6(immune-mod)6.5(ulating)-460.1(and)-457.5(anti-inammatory)]TJ
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[(mediated)-465.9(inammation,)-463.8(oral)-461.4(daily)-465(administration)-463.1(of)]TJ
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[(CBD)-354.8(at)-357.7(doses)-360.5(ranging)-355.3(from)-355.8(5)-353.9(t)0(o)-356.8(4)0(0)-169.8(mg/kg)-352.8(for)-355.6(3)-359.1(days)]TJ
T*
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[(levels,)-556(tissue)-557.2(cyclooxygenase)-554.8(activity,)-556.8(production)-554.3(of)]TJ
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[(oxygen-derived)-550.3(free)-551.2(radicals,)-551.8(and)-550.6(nitric)-547.1(oxide)-551.9(after)]TJ
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[(three)-355.9(doses)-355.4(of)-357.5(CBD.)]TJ
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(30)Tj
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[(Anti-inammat)6(ory)-359.3(effects)-354.5(may)]TJ
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[(be)-429(explained)-424.4(by)-428.4(inverse)-424.6(agonism)-430.3(activity)-423(toward)-428.1(the)]TJ
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[(CB2)-304.7(receptor,)]TJ
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(31)Tj
10.959 0 0 10.959 131.6409 283.4078 Tm
[(which)-295.8(inhibits)-303.2(immune)-301.6(cell)-302.7(migration)]TJ
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[(both)-676(in)-673.4(macrophages)]TJ
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(32)Tj
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[(and)-669.6(human)-676.8(neutrophils.)]TJ
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(33)Tj
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[(CBD)-235.8(may)-238.1(also)-238.9(exert)-243(potent)-243.6(and)-240.2(specic)-243(acti)-7.6(vity)-239.5(against)]TJ
T*
[(neu)-7.7(roinammation)-304(proce)-8.5(sses,)-301.9(which)-300.9(are)-303.9(involved)-306.2(in)-295.7(a)]TJ
T*
[(number)-307.9(of)-300.5(n)-12.5(e)-8.2(u)-7.7(r)-13.6(o)-7(d)-12.8(e)-8.2(g)-7.6(e)-13.4(n)-7.4(e)-13.4(r)-8.5(a)-7.9(t)-13.6(i)-9(v)-7.6(e)-313.4(d)-7.7(i)-9(s)-13.6(o)-7(r)-8.5(d)-12.8(e)-8.2(r)-8.5(s)-13.6(.)]TJ
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.0107 Tc
(34)Tj
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0 Tc
[(In)-284.8(an)-289.4(experimental)-286.8(murine)-289.2(multiple)-286.1(sclerosis)-287.1(model)]TJ
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T*
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T*
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(42)Tj
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[(In)-555.3(an)]TJ
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[(chemotactic)-304.8(p)1(rotein-1)-303.9(\(MCP-1)]TJ
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[(with)-335.5(potent)-336.7(antioxida)-10.1(nt)-331.3(activi)-8.7(ty)-331.5(found)-338.8(in)-337.1(hemp)-333.5(ino-)]TJ
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(46)Tj
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[(effects)-307.9(in)-300.9(humans.)]TJ
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(47)Tj
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[(Hemp)-299.7(Supplements)]TJ
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[(As)-303.9(a)-303.3(p)2.1(lant-derived,)-299.9(e)1.6(asily)-297.8(e)-3.6(xt)]TJ
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[(ractable,)-304.9(b)2.9(iologically)-302.9(ac-)]TJ
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[(tiv)-4.1(e)-630.6(compou)-4.1(nd)-635.3(wi)-5.5(th)-629.4(l)-5.1(a).8(rg)-4.1(e)-630.6(t).3(hera)-4.4(pe)-4.7(uti)-5.5(c)-630.6(index)-635.5(a).8(nd)]TJ
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[(A)-305.3(REVIEW)-309.7(OF)-302.7(HEMP)-303.3(AS)-303.5(FOO)-10.1(D)-297.5(AND)-308.4(SUPPLE)-9.9(MENT)-26180.8(21)]TJ
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(48,49)Tj
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[(disorder,)-302.2(depression,)-302.2(and)-297.1(Parkinsons)-300.4(disease.)]TJ
8.2191 0 0 7.3052 263.055 456.6613 Tm
(50)Tj
10.959 0 0 10.959 72.9637 438.8597 Tm
[(W)11(h)0(i)20.2(l)0(e)-192.7(C)0(B)18.1(D)-197(ha)16.1(s)-199.9(b)0(e)21(e)0(n)-191.4(a)0(d)20.6(m)10.2(in)19.8(is)18.7(t)12.3(e)0(r)19.5(e)0(d)-196.9(u)13(p)-204.2(t)12.3(o)-203.6(6)13.4(00)21.7(0)-157.3(m)10.2(g/)19.5(da)20.6(y)]TJ
-.9984 -1.1847 TD
[(i)11.7(n)-281.5(ph)21.5(as)19.8(e)-277.2(I)-282.6(s)12.2(t)0(u)20.2(d)0(i)19.5(e)0(s)19.5(,)]TJ
8.2191 0 0 7.3052 139.5212 430.7527 Tm
(51)Tj
10.959 0 0 10.959 150.3496 425.877 Tm
[(Ep)16.3(i)11.7(d)0(i)19.5(o)13.7(le)19.4(x)-282.1(r)12.2(ec)19.8(om)18.7(m)10.2(e)12.5(nd)21.2(ed)-269.4(th)20.8(at)-269.8(s)12.2(t)0(a)19.9(r)0(t)19.4(-)]TJ
-8.0598 -1.1795 TD
[(i)11.7(n)0(g)-263.3(d)13(os)20.8(e)-272(f)11.6(or)-258.6(t)12.3(h)0(e)-258.4(a)0(p)15.5(p)13(ro)20.8(ve)20.4(d)-271.5(i)11.7(nd)21.2(ic)19(at)19.9(io)20.2(ns)-259(i)11.7(s)-272.3(5)-157.3(m)15.3(g/)19.5(kg)15.8(,)-268.3(w)0(h)23.3(i)0(c)19(h)]TJ
0 -1.1847 TD
[(ca)20.1(n)-416(b)0(e)-403.2(i)0(n)19.8(c)0(r)19.5(e)0(a)20.1(s)0(e)19.5(d)-416.3(up)-408.5(t)12.3(o)-415.6(20)-143.9(m)10.2(g)0(/)19.5(k)0(g)21(/)0(d)14.3(a)12.8(y.)]TJ
8.2191 0 0 7.3052 230.0598 404.844 Tm
-.0169 Tc
(52)Tj
10.959 0 0 10.959 242.3621 399.9684 Tm
0 Tc
[(Co)17.9(m)10.2(p)13(ar)19.8(ed)-409(t)12.3(o)]TJ
-16.4559 -1.1795 TD
[(pl)19.9(ac)20.1(eb)21(o,)-233.9(E)13.6(p)0(i)19.5(d)0(i)19.5(o)0(l)20.6(e)0(x)-228.2(h)0(a)16.1(s)-241.3(s)12.2(h)0(o)22.2(w)0(n)-230.5(d)0(o)21.6(s)0(e)19.5(-)0(d)20.4(e)0(p)20.3(e)0(n)15.5(d)13(en)20.6(t)-241.2(i)11.7(nc)15.5(r)12.2(e)0(a)20.1(s)0(e)19.5(d)]TJ
0 -1.1847 TD
[(i)11.7(n)0(c)15.5(i)11.7(de)20.3(nc)20.6(e)-339.3(o)0(f)-326.4(a)0(l)19.7(a)0(n)21(i)0(n)19.8(e)-339.3(am)23(in)19.8(ot)20.8(ra)19.8(ns)15.2(f)11.6(e)12.5(ra)19.8(se)-332.2(e)12.5(l)12(ev)15.2(a)12.8(t)12.3(io)20.2(ns)-331.4(a)12.8(b)0(o)22.3(v)0(e)]TJ
0 -1.1795 TD
[(t)12.3(h)0(r)15.6(i)11.7(c)12.5(e)-380.7(t)12.3(h)0(e)-367(u)0(p)15.7(p)13(er)-368.4(l)12(i)0(m)16.7(i)11.7(t)-375.7(o)0(f)-367.8(n)0(o)16.7(r)12.2(m)10.2(a)0(l)-368.3(\()11.9(13)21.6(%)-377.8(v)0(s)20.2(.)-376.9(1%)18.5(,)-376.9(m)10.2(ai)19.3(nl)20.2(y)]TJ
T*
[(i)11.7(n)-312.6(pa)20.6(ti)18.8(e)12.5(n)0(t)20.5(s)-313.7(t)12.3(r)0(e)19.5(a)0(t)19.9(e)0(d)-300.4(a)0(t)-300.8(t)12.3(he)-299.7(20)-149.1(m)10.2(g)13.1(/k)19.5(g)-312.8(d)13(ai)19.3(l)12(y)-312.8(d)13(o)0(s)20.8(e)0(\))19.2(.)]TJ
8.2191 0 0 7.3052 264.5291 353.0267 Tm
-.0169 Tc
(52)Tj
10.959 0 0 10.959 275.6976 348.2078 Tm
0 Tc
[(Do)23.6(se)19.5(-)]TJ
-19.4977 -1.1847 TD
[(de)20.3(pe)20.3(nd)16(e)12.5(n)0(t)-512.4(C)0(B)23.3(D)-522.9(p)13(o)0(t)20.8(e)0(n)15.5(t)12.3(i)11.7(a)0(l)-513.2(f)11.6(or)-512.1(i)11.7(n)0(d)16(u)13(ci)19(ng)-511.6(l)12(i)0(v)19.6(e)0(r)-513.3(t)12.3(ox)21.3(ic)19(it)18.8(y)]TJ
0 -1.1795 TD
[(wh)18.2(e)12.5(n)-483.3(a)12.8(d)0(m)18(i)11.7(ni)19.8(st)19.4(e)12.5(r)0(e)19.5(d)-483.6(at)-471.5(ph)21.5(ar)19.8(m)10.2(a)0(c)20.1(o)0(l)20.6(o)0(g)21.6(i)0(c)19(a)0(l)-471.8(d)0(o)21.6(s)0(e)19.5(s)-484.4(i)11.7(s)-479.2(co)15.9(n)13.3(-)]TJ
0 -1.1847 TD
[(r)20.7(m)10.2(e)0(d)-196.9(b)0(y)-195.6(p)13(re)19.5(-c)19.9(li)18.5(ni)19.8(ca)20.1(l)-205.2(e)0(x)20.1(p)0(e)20.3(r)0(i)18.7(e)0(n)20.7(c)0(e)19.8(s)-205(in)-197.4(th)20.8(e)-204.8(m)10.2(ou)16.4(s)12.2(e)-204.8(m)10.2(o)0(d)21.6(e)0(l)19.3(.)]TJ
8.2191 0 0 7.3052 293.3857 314.192 Tm
-.0168 Tc
(53)Tj
10.959 0 0 10.959 72.9637 296.3904 Tm
0 Tc
[(In)-212.4(Epidiolex)-206.7(registrative)-208.4(trials,)-205.4(somnolence)-210.3(and)-204(seda-)]TJ
-.9984 -1.1847 TD
[(tion)-388.7(were)-387.7(reported)-384.8(in)-388.8(34%)-382(and)-390.2(27%)-387.1(of)-383.3(patients)-391.3(con-)]TJ
0 -1.1795 TD
[(suming)-593.8(20)-594(versus)-592.1(10)-164.6(mg/kg/day,)-596.5(while)-587.1(the)-597.8(risk)-592.3(of)]TJ
0 -1.1847 TD
[(suicidal)-289(behavior)-289.8(associated)-288.1(with)-288.9(Epidiolex)-289.5(versus)-292(pla-)]TJ
0 -1.1795 TD
[(cebo)-216.6(was)]TJ
/F9 1 Tf
3.7454 0 TD
(*)Tj
/F7 1 Tf
.9984 0 TD
[(3.5)-220.8(fold.)]TJ
8.2191 0 0 7.3052 148.8188 249.4488 Tm
(48)Tj
10.959 0 0 10.959 159.0803 244.5731 Tm
[(Decreased)-215.8(appetite,)-219.9(fatigue,)-222.6(diar-)]TJ
-8.8565 -1.1795 TD
[(rhea,)-367.1(transaminase)-369(elevation,)-366.5(rash,)-367.4(sleep)-367.1(disorders,)-372.7(as)]TJ
0 -1.1847 TD
[(well)-305.6(as)-311.2(infections,)-308.9(were)-310.1(a)12.8(l)0(s)19.1(o)-301.8(re)19.5(po)16.4(rt)19.4(ed)-290(in)]TJ
/F11 1 Tf
16.3317 0 TD
(>)Tj
/F7 1 Tf
.7087 0 TD
[(1)13.4(0)0(%)-291.9(o)0(f)-290.2(s)12.2(ub)16.4(-)]TJ
-17.0404 -1.1795 TD
[(je)19.4(ct)14.4(s)-329.2(t)0(r)19.3(e)0(a)14.9(t)12.3(ed)-326.3(wi)21.3(th)-320.6(Ep)16.3(id)19.5(io)15.1(l)12(e)0(x)14.9(.)]TJ
8.2191 0 0 7.3052 182.948 210.6141 Tm
(48)Tj
10.959 0 0 10.959 194.3999 205.7385 Tm
[(I)12.3(n)-333.3(vi)19.6(ew)-324.5(o)13.7(f)-335(t)12.3(h)0(e)-325.6(v)0(a)20.7(r)0(i)18.7(e)0(t)14.4(y)-328.3(of)]TJ
-12.0794 -1.1847 TD
[(po)16.4(t)12.3(e)0(n)15.5(t)12.3(ia)14.1(l)12(l)0(y)-300.8(l)12(if)18.2(e-)14.7(t)12.3(h)0(r)15.6(e)12.5(at)14.7(en)20.6(in)14.7(g)-307.6(a)12.8(dv)15.8(er)19.5(se)-301.2(ev)20.4(en)15.5(ts)19.4(,)-309.7(a)0(s)-300.9(w)0(e)22.1(l)0(l)-301.8(a)12.8(s)-308.5(o)0(f)]TJ
0 -1.1795 TD
[(th)15.6(e)-463.4(r)0(e)14.4(c)12.5(om)18.7(me)17.5(nd)16(ed)-460.8(p)13(r)0(e)14.4(c)12.5(au)15.5(ti)18.8(on)16.7(s)-468.9(a)12.8(nd)-459.9(wa)17.3(rn)20.4(in)14.7(g)13.1(s)0(,)-463(b)0(e)21(s)0(i)13.6(d)13(es)]TJ
0 -1.1847 TD
[(po)16.4(t)12.3(e)0(n)15.5(t)12.3(ia)14.1(l)-303.5(d)0(r)14.9(u)13(g)16.1(dr)20.1(ug)-299.8(in)19.8(te)14.4(r)12.2(a)0(c)14.9(t)12.3(io)15.1(n)13.3(s)-308.5(re)19.5(po)16.4(rt)19.4(ed)-300.4(wi)21.3(th)-299.9(CB)18.1(D)-305.6(a)12.8(t)]TJ
0 -1.1795 TD
[(ph)16.4(a)12.8(r)0(m)17.2(a)0(c)14.9(o)13.7(lo)15.4(gi)19.6(ca)20.1(l)-225.9(d)0(o)16.4(s)12.2(es)14.4(,)-226.9(t)12.3(he)-217(FD)17.8(A)-223.5(h)0(a)16.1(s)-220.6(pr)14.9(oh)22.2(ib)15.1(i)11.7(t)0(e)14.4(d)-224.9(m)10.2(a)0(r)19.8(k)0(e)15.2(t)12.3(-)]TJ
0 -1.1847 TD
[(in)19.8(g)-488.7(o)13.7(f)-485(C)0(B)18.1(D)-486.7(a)12.8(s)-484.4(an)-475.7(in)14.7(g)13.1(r)0(e)14.4(d)0(i)19.5(e)0(n)15.5(t)-484.3(f)11.7(o)0(r)-475.9(n)0(u)16(t)12.3(ri)13.6(t)12.3(i)0(o)20.2(n)0(a)15.8(l)-484.6(su)20.1(pp)15.7(le)19.4(-)]TJ
0 -1.1795 TD
-.0102 Tc
[(me)-10.2(n)5.3(t)2.1(s)-10.2(,)]TJ
8.2191 0 0 7.3052 90.4819 132.8882 Tm
0 Tc
(18)Tj
10.959 0 0 10.959 103.0677 128.0126 Tm
[(wh)18.2(i)11.7(c)0(h)-429.1(a)0(p)15.5(p)0(e)20.3(a)0(r)14.7(s)-432.7(in)-430.2(co)21(nt)15.3(ra)19.8(di)14.4(c)12.5(t)0(i)18.8(o)0(n)-428.2(w)0(i)16.2(t)12.3(h)-436.4(U)0(n)18.1(i)0(t)18.8(e)0(d)]TJ
-3.7454 -1.1847 TD
[(St)19.9(at)14.8(e)12.5(s)-634.4(fe)19(de)15.2(ra)19.8(l)-634.6(c)0(o)21(u)0(r)14.9(t)-634.3(r)12.2(u)0(l)14.7(i)11.7(ng)-625.4(e)12.5(s)0(t)14.2(a)12.8(bl)15.4(i)11.7(s)0(h)15.6(i)11.7(ng)-625.4(t)12.3(h)0(a)16.1(t)-634.3(he)21(m)10.2(p)0(-)]TJ
0 -1.1795 TD
[(de)15.2(r)12.2(i)0(v)14.4(e)12.5(d)-633.6(p)0(r)14.9(o)13.7(du)15.7(ct)19.6(s,)-623.4(in)14.7(c)12.5(l)0(u)14.7(d)0(i)19.5(n)0(g)-625.4(t)12.3(ho)17.1(se)-621.9(co)15.9(nt)20.5(ai)19.3(ni)14.7(ng)-620.2(CB)18.1(D,)]TJ
T*
[(co)15.9(u)13(l)0(d)-285.3(b)0(e)-279(f)0(r)18.7(e)0(e)14.6(l)12(y)-292.1(m)10.2(ar)14.7(k)13.1(e)0(t)14.4(e)12.5(d)-292.2(u)0(n)16(d)0(e)20.3(r)-293(th)20.8(e)-292.7(2)0(0)16.5(1)13.4(4)-291.8(F)0(a)15.5(r)12.2(m)-289.9(B)0(i)15.3(l)12(l.)]TJ
8.2191 0 0 7.3052 284.5983 93.9968 Tm
(54)Tj
10.959 0 0 10.959 72.9637 76.1953 Tm
[(Th)17.2(e)-199.6(s)0(c)19.5(e)0(n)20.6(a)0(r)19.8(i)0(o)-191.9(i)0(s)-193.4(a)0(l)19.7(s)0(o)-191.3(c)0(o)21(n)0(f)19.8(u)0(s)14.9(i)11.7(ng)-190.8(i)11.7(n)-203.9(Eu)21.5(ro)15.6(p)13(e)0(,)-193.7(w)0(h)23.3(e)0(r)19.5(e)-204.8(CB)23.3(D-)]TJ
-.9984 -1.1795 TD
[(co)21(nt)20.5(ai)19.3(ni)19.8(ng)-211.5(pr)20.1(od)16.4(u)13(c)0(t)19.6(s)-225.7(\()11.9(e)0(.)18.4(g)13.1(.,)-215.8(CB)23.3(D-)17.3(e)12.5(n)0(r)20.4(i)0(c)19(h)0(e)21(d)-224.9(he)21(m)10.2(p)-224.9(o)13.7(i)0(l)18.5(\))-220.9(ha)16.1(v)13.1(e)]TJ
22.9068 57.9085 TD
[(be)15.9(e)12.5(n)-281.5(cl)19.3(as)19.8(si)18.7(e)21(d)-281.8(a)0(s)-275(n)0(o)21.9(v)0(e)20.4(l)-282.8(fo)20.2(od)21.6(s)-287.8(b)13.7(ec)19.8(au)20.7(se)-275.3(t)12.3(h)0(e)21(i)0(r)-276.1(u)13(se)-275.3(wa)22.4(s)-282.6(n)0(o)16.7(t)]TJ
0 -1.1847 TD
[(wi)16.2(d)13(e)0(s)19.5(p)0(r)20.1(e)0(a)20.1(d)-452.6(i)11.7(n)-452.2(Eu)16.3(r)12.2(o)0(p)21.6(e)-453.1(b)13.7(e)0(f)19(o)0(r)20.8(e)-453.1(19)21.6(97)21.6(,)]TJ
8.2191 0 0 7.3052 470.381 689.7825 Tm
-.0169 Tc
(55)Tj
10.959 0 0 10.959 483.0802 684.9069 Tm
0 Tc
[(wh)23.3(ic)19(h)-451.9(m)10.2(ak)20.7(es)-440.9(it)]TJ
-15.5143 -1.1795 TD
[(m)10.2(a)0(n)15.8(d)13(at)19.9(or)20.8(y)-390.4(t)12.3(o)-389.8(a)12.8(pp)15.7(l)12(y)-390.4(f)11.6(o)0(r)-377.6(a)0(u)20.6(t)0(h)20.8(o)0(r)20.8(i)0(z)19(a)0(t)19.9(i)0(o)20.2(n)-390.2(t)12.3(o)-389.8(pl)19.9(a)12.8(c)0(e)-383.7(d)13(ie)19(t)12.3(a)0(r)19.8(y)]TJ
0 -1.1847 TD
[(CB)18.1(D)-284.9(p)0(r)20.1(o)0(d)21.6(u)0(c)20.3(t)0(s)-280.7(o)13.7(n)-286.7(t)0(h)20.8(e)-287.5(m)10.2(a)12.8(rk)14.9(e)12.5(t)12.3(.)-289(O)0(n)17.7(e)-282.4(ap)20.7(pl)19.9(ic)19(at)19.9(io)20.2(n)-286.7(r)0(e)19.5(q)0(u)21.2(e)0(s)19.5(t)0(-)]TJ
0 -1.1795 TD
[(in)19.8(g)-328.3(C)14.5(BD)-317.6(t)12.3(o)-322.5(be)-315.2(a)12.8(u)0(t)20.1(h)0(o)17(r)12.2(i)11.7(z)0(e)19.8(d)-328.4(a)12.8(s)-324(a)-328.6(n)13.3(ov)21.7(el)-316.9(f)11.7(o)0(o)22.3(d)-328.4(w)14.8(i)0(t)18.8(h)-322.6(a)-328.6(d)13(ai)19.3(l)12(y)]TJ
0 -1.1847 TD
[(in)19.8(ta)19.9(ke)-326.2(of)-321.2(up)-325.7(to)-325.8(1)13.4(3)0(0)-149.1(m)10.2(g)-333.5(o)13.7(r)-334.4(1)0(.)19.3(8)0(6)-143.9(m)10.2(g/)19.5(kg)-325.6(b)13.7(o)0(d)16.4(y)-333.5(we)22.1(i)11.7(g)0(h)16.4(t)-329.1(ha)16.1(s)]TJ
0 -1.1795 TD
[(be)15.9(e)12.5(n)-291.9(l)20.5(ed)-284.9(by)-283.6(Ca)22.1(nn)16.3(a)12.8(b)0(i)20.2(s)-293(Ph)17(a)12.8(r)0(m)17.2(a)12.8(,)-294.1(s)0(.)18.1(r)12.2(.o)19.6(.)-294.1(\()0(C)21.3(z)0(e)19.8(c)0(h)-284.2(R)0(e)16(p)13(ub)21.6(li)18.5(c\))]TJ
T*
[(an)15.8(d)-287(r)0(e)19.5(m)10.2(ai)19.3(ns)-279.7(cu)20.3(rr)19.3(en)20.7(tl)19.2(y)-292.1(p)13(en)20.7(di)19.5(ng)21.3(.)]TJ
8.2191 0 0 7.3052 449.2912 612.0565 Tm
-.0169 Tc
(56)Tj
10.959 0 0 10.959 324.0566 594.2549 Tm
0 Tc
[(Despite)-324.6(such)-326.2(a)-323.5(regulatory)-328.2(and)-323(legislative)-329.7(confusion,)]TJ
-1.0036 -1.1795 TD
[(the)-308.1(importance)-300(of)-305.7(the)-303(CBD)-303(issue)-305.7(from)-304(a)-302.8(public)-301.7(health)]TJ
0 -1.1847 TD
-.0001 Tc
[(perspective)-457.5(lies)-458.6(in)-456.2(its)-455.3(widespread)-456.9(self-administration)]TJ
0 -1.1795 TD
0 Tc
[(without)-322.3(any)-322.9(medical)-324(supervision)-321.7(and)-323(wide)-320.4(availability)]TJ
0 -1.1847 TD
[(as)-368.1(a)-364.8(supplement,)-366.7(with)-361.4(a)-364.8(market)-366.7(worth)-362.6(for)-365.9(retail)-366.2(sales)]TJ
0 -1.1795 TD
[(of)-512.6(hemp-derived)-517.4(CBD)-510(products)-513.6(of)-512.6($170)-510.2(million)-510.3(in)]TJ
0 -1.1847 TD
[(2016)-246.4(in)-244(the)-240.9(United)-242.8(States)-245.9(alone)-246(and)-240.2(a)-245.9(projected)-243.2(market)]TJ
0 -1.1795 TD
[(worth)-331.6(of)-336.8(hemp-deriv)5.4(ed)-336.6(CBD)-328.9(of)-331.6($22)-332.2(billion)-330.8(in)-337.1(2022.)]TJ
8.2191 0 0 7.3052 544.3085 508.4786 Tm
(57)Tj
10.959 0 0 10.959 313.0582 490.677 Tm
[(Furthermore,)-337.7(in)-331.9(view)-335.9(of)-331.6(the)-334(lack)-337.6(of)-331.6(stringent)-331.9(controls)]TJ
0 -1.1847 TD
[(of)-481.6(marketed)-475.7(products)-477.4(by)-475(the)-478.9(competent)-472.3(authorities,)]TJ
0 -1.1795 TD
[(mislabeling)-480.4(of)-476.4(CBD)-478.9(supplements)-479.3(is)-477.9(frequent,)-477.8(which)]TJ
0 -1.1847 TD
[(may)-351.9(represent)-358(a)-349.3(fraud)-356.3(for)-350.4(consumers,)-353(as)-352.6(well)-352.1(as)-352.6(pose)]TJ
0 -1.1795 TD
[(a)-302.8(risk)-297.4(for)-303.8(their)-299.8(health.)]TJ
1.0036 -1.1847 TD
[(In)-222.7(a)-225.2(study)-220.9(involving)-221.2(88)-226.7(CBD)-220.3(liquid)-225.2(products,)-223.2(includ-)]TJ
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[(ing)-298.1(oil)-293.7(and)-291.9(vaporization)-292(liquid,)-296.9(marketed)-294.6(by)-288.7(31)-293.9(differ-)]TJ
0 -1.1847 TD
[(ent)-391.3(companies,)-389.2(CBD)-391(median)-392.1(levels)-386(were)-392.9(9.45)-166(mg/mL)]TJ
0 -1.1795 TD
[(\(range)-529.4(0.10655.27)-167.6(mg/mL\),)-528.8(which)-523.4(was)-529.2(lower)-529.6(com-)]TJ
0 -1.1847 TD
[(pared)-903.8(to)-900(the)-903.1(median)-904.3(labeled)-899.5(concentration)-899.5(of)]TJ
0 -1.1795 TD
[(15.00)-168.1(mg/mL)-701.8(\(range)-705.3(1.33800.00\).)-703.3(CBD-containing)]TJ
T*
[(oil)-360.9(to)-356.8(be)-356.6(consumed)-354.8(orally)-358.7(was)-358.5(inaccurately)-356.2(labeled)-356.3(in)]TJ
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[(55%)-382(of)-383.3(cases.)]TJ
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(58)Tj
10.959 0 0 10.959 385.1716 335.2251 Tm
[(The)-384.1(FDA)-381.6(has)-380.3(sent)-384.2(warning)-384.6(letters)-379.5(to)]TJ
-6.5803 -1.1795 TD
[(several)-455.8(companies)-452(requesting)-453.2(them)-453.2(to)-449.9(stop)-450.5(claiming)]TJ
0 -1.1847 TD
[(that)-243.8(their)-242.9(CBD)-235.8(products)-244.6(may)-238.1(treat)-243.1(or)-243.1(even)-238.3(cure)-244.6(serious)]TJ
0 -1.1795 TD
[(diseases,)-303.7(including)-300.2(cancer.)]TJ
8.2191 0 0 7.3052 428.5416 301.2661 Tm
(59)Tj
10.959 0 0 10.959 324.0566 283.4078 Tm
.0091 Tc
[(The)-521.6(w)-1.9(ide)-4.3(s).6(pr)-4.5(ead)-526.2(u)1.4(se)-521.6(of)-522.4(CBD)-519(p)-3.7(roducts)-521.9(h)-3.1(as)-521.9(been)]TJ
-1.0036 -1.1795 TD
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[(poorly)-427.1(investigated.)-423.9(O)-1.2(ne)-422.5(st)]TJ
11.4224 0 TD
.0117 Tc
[(u)4(d)-1.1(y)-420.1(r)3.2(ec)3.5(ruited)-420.2(24)4.4(09)-419.8(ind)4(i)-2.5(-)]TJ
-11.4224 -1.1847 TD
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[(viduals)-247.3(w)-1.5(ho)-251(participated)-251.6(in)-246.2(an)-246.2(onli)-4.7(ne)-252.2(survey)-251.6(designed)]TJ
0 -1.1795 TD
.0122 Tc
[(to)-481(a)4.3(s)3.7(se)4(s)3.7(s)-482.6(t)3.8(h)0(e)-477.1(r)-1.4(e)4(a)4.3(so)5.2(ns)3.7(,)-483.7(r)3.7(is)3.7(ks)3.7(,)-483.7(a)4.3(nd)-476.6(mod)4.5(a)4.3(lit)3.8(i)3.2(es)-477.4(be)4(hin)4.8(d)]TJ
T*
.0099 Tc
[(CBD)-388.9(c)-3.5(onsumption.)]TJ
8.2191 0 0 7.3052 400.7621 236.4661 Tm
.0176 Tc
(60)Tj
10.959 0 0 10.959 413.1779 231.6472 Tm
.0099 Tc
[(Approximately)-396(a)-391.2(third)-396.1(o)2.9(f)-392.3(p)-2.9(ar-)]TJ
-9.1358 -1.1847 TD
.0092 Tc
[(t)-4.4(i).2(ci)-5(pants)-563.1(r).7(epor)-4.4(ted)-562.3(s).7(om)9.2(e)-568.2(n)]TJ
11.3344 0 TD
.0095 Tc
[(ons)-4.1(e)1.3(rious)-562.8(a)1.6(dverse)-562.6(event)-4.1(,)]TJ
-11.3344 -1.1795 TD
.0092 Tc
[(wit)-4.4(h)-504.8(the)-506(m)-1.3(os)-4.4(t)-506.2(f).2(requentl)-4.6(y)-505.4(o)2.2(ccur)-4.4(ring)-505.4(advers)-4.4(e)-506(e)1(vent)-4.4(s)]TJ
0 -1.1847 TD
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[(be)3.9(in)4.7(g)-440.4(d)4.4(r)3.6(y)-440.4(mo)5.1(ut)3.7(h)-434.6(\()-1.9(1)4.8(1)-.4(.1)4.8(2%)6.8(\),)-437.2(e)3.9(u)-.7(p)4.4(h)-.1(o)5.1(r)3.6(ia)-435.5(\()3.3(6)-.4(.4)4.8(3%\))3.3(,)-437.2(hu)4.4(n-)]TJ
0 -1.1795 TD
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[(ger)-454.3(\()-4.6(6.35%\),)-455.5(r).9(e)-4(d)-453.5(eyes)-454.3(\()-4.6(2)2.1(.74%\),)-455.5(and)-453.5(s)-4.2(edation/)-4.9(fati)-4.8(gue)]TJ
0 -1.1847 TD
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0 -1.1795 TD
.0089 Tc
[(CBD)-426.1(t).5(o)-427.4(t).5(re)-4.5(at)-428.9(a)-428.4(m)8.9(e)-9.8(d)1.2(ic)-4.5(al)-429.1(cond)]TJ
12.4673 0 TD
.0097 Tc
[(ition,)-429.3(which)-421.5(m)-.8(ost)-428.1(f).7(re-)]TJ
-12.4673 -1.1847 TD
.0105 Tc
[(quen)3.1(tly)-312.6(i)1.5(ncluded)-312.7(p)-2.3(ain,)-314.7(anxi)]TJ
11.3137 0 TD
.0097 Tc
[(ety,)-315.5(depressi)-4.5(on,)-315.5(a)1.8(nd)-313.5(sl)-4.1(eep)]TJ
-11.3137 -1.1795 TD
[(disorders)-4(,)-610.5(approximat)-4(ely)-608.4(o)-2.5(ne-third)-608.5(of)-609.9(participants)]TJ
0 -1.1847 TD
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[(s)-4.6(t).6(at)-4.6(ed)-443.6(t)-4.6(h)2(a)-4.1(t)-444.3(CBD)-441.5(a)-4.1(lone)-444.1(coul)-4.8(d)-443.6(m)-1.5(anage)-449.3(t).6(he)-4.4(ir)-444.4(medica)-4.1(l)]TJ
0 -1.1795 TD
.0097 Tc
[(condition)-302.9(b)2.7(y)-303.1(i).7(tself.)]TJ
1.0036 -1.1795 TD
0 Tc
(Importantly,)Tj
/F9 1 Tf
5.3698 0 TD
(*)Tj
/F7 1 Tf
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[(40%)-335.4(of)-336.8(participants)-336.4(were)-341.1(motivated)]TJ
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[(to)-299.9(consume)-295.4(CBD)-297.9(as)-295.7(part)-296.3(of)-295.4(a)-297.6(healthy)-297.9(lifestyle.)-298(Despite)]TJ
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[(its)-465.6(numerous)-468.9(limitations,)-460.3(including)-465.7(the)-468.5(lack)-461.8(of)-466.1(data)]TJ
/F4 1 Tf
9.9626 0 0 9.9626 62.022 754.3557 Tm
(22)Tj
42.7246 0 TD
[(CERINO)-310.1(ET)-299.4(AL.)]TJ
ET
endstream
endobj
58 0 obj
<>stream
/GS1 gs
BT
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10.959 0 0 10.959 59.7543 697.8896 Tm
0 0 0 rg
0 Tc
0 Tw
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[(study)-272.6(has)-271.7(the)-266.7(merit)-272.2(to)-268.8(capture)-273.8(consumers)-270.2(motivations)]TJ
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[(behind)-242.8(CBD)-241(use,)-240.9(which)-244(is)-239.9(essential)-240.2(to)-243(direct)-241.4(further)-243.5(re-)]TJ
0 -1.1795 TD
[(search)-374.2(and)-374.7(investigations,)-371.7(as)-373.3(well)-372.8(as)-373.3(regulatory)-369.6(inter-)]TJ
0 -1.1847 TD
(ventions.)Tj
1.0036 -1.1795 TD
[(Despite)-376.3(the)-380.6(large)-377.1(consumption)-373.2(of)-378.1(CBD)-380.6(as)-378.5(a)-375.2(nutri-)]TJ
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[(ingredient)-319.3(is)-317.5(scarce)-318.5(to)-315.4(nonexisting.)-314.6(In)-315.8(one)-317.4(pre-clinical)]TJ
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[(study)-376.1(conducted)-375.6(in)-378.5(eight)-376.5(dogs)-372.1(and)-374.7(eight)-376.5(cats,)]TJ
8.2191 0 0 7.3052 265.3228 573.2219 Tm
(61)Tj
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(CBD)Tj
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[(administered)-602.7(at)-600.9(the)-603(daily)-599.5(dose)-600.4(of)-600.6(4)-162.5(mg/kg)-601.1(for)-603.9(12)]TJ
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[(weeks)-343.6(did)-339.9(not)-338.3(cause)-340.5(any)-338.4(alteration)-334.8(in)-342.3(complete)-335.9(blood)]TJ
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[(count)-369.7(or)-372.4(serum)-369.3(chemistry,)-364.9(with)-371.7(the)-365(exception)-372(of)-367.8(one)]TJ
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[(cat)-246.9(showing)-238.5(persistent)-243(abnormalities)-242.4(in)-244(alanine)-242.6(amino-)]TJ
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[(transferase)-365.1(levels.)-359.5(Dogs)-359.7(presented)-362.4(few)-359.4(adverse)-361.7(events,)]TJ
T*
[(in)9.5(clu)11.7(di)9.2(ng)-294.3(lo)15.4(os)10.4(e)-303.1(sto)17.5(ol)-295(an)10.6(d)-302.5(v)0(o)11.3(m)0(i)11.5(tin)16.6(g)-302.5(o)0(c)10.7(c)0(u)10(rri)15.4(ng)-294.3(fo)9.8(r)]TJ
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19.8857 0 TD
(<)Tj
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(5%)Tj
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0 -1.1847 TD
[(obs)13.8(er)9.2(ve)10.1(d)-287(f)0(o)9.8(r)-293(35)11.3(.4)14.1(%)-289.8(a)0(n)10.6(d)-292.2(25)11.3(.2%)-275.7(of)-285(th)10.5(e)-287.6(obs)13.8(er)9.2(va)10.4(tio)17(n)-291.9(t)0(i)13.6(me,)]TJ
0 -1.1795 TD
[(re)9.2(sp)9.7(ec)9.5(tiv)16.4(ely)11.8(.)]TJ
1.0036 -1.1847 TD
[(In)-279.6(a)-276.9(small)-277(interventional)-278.5(prospective)-280.3(trial,)-279.7(including)]TJ
-1.0036 -1.1795 TD
[(12)-206(individuals)-209(receiving)-203(up)-206.7(to)-206.8(90)-164.6(mg)-204.4(of)-207.4(single)-204.5(oral)-207.9(doses)]TJ
0 -1.1847 TD
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[(of)-331.7(CBD)-329(and)-328.2(assessed)-335(for)-329.8(cardiovascular)-329.3(and)-333.4(cognitive)]TJ
0 -1.1795 TD
0 Tc
[(functions)-382.9(after)-383.4(CBD)-385.8(consumption,)-377.6(increased)-383.9(cerebral)]TJ
0 -1.1847 TD
[(perfusion)-336.7(and)-338.5(reduced)-340.6(blood)-332.1(pressure)-339.8(compared)-334.7(with)]TJ
0 -1.1795 TD
[(baseline)-220(were)-211.8(reported)-219.3(in)-212.9(a)-220(subgroup)-211.5(of)-217.8(participants)-217.4(re-)]TJ
T*
[(ceiving)-310.5(90)-164.6(mg)-302.7(CBD,)-307.5(without)-301.6(any)-307.4(clinically)-305.7(evident)-304.7(ad-)]TJ
0 -1.1847 TD
[(verse)-423.8(events)-420.7(or)-424.1(laboratory)-419.8(alteration)-422.7(in)-419.9(blood)-420.1(count,)]TJ
0 -1.1795 TD
[(inammation,)-298.2(or)-300(metabolic)-297.3(markers.)]TJ
8.2191 0 0 7.3052 221.6125 327.1747 Tm
(62)Tj
10.959 0 0 10.959 70.7527 309.3164 Tm
[(Although)-214.7(adequate)-218.5(trials)-216.4(assessing)-218.8(CBD)-220.3(effects)-219.9(when)]TJ
-1.0036 -1.1795 TD
[(administered)-292.3(as)-285.4(nutritional)-285.8(supplement)-289.8(in)-290.5(large)-284(popu-)]TJ
0 -1.1847 TD
[(lations)-284.4(and)-286.8(for)-283.2(a)-287.2(prolonged)-281.7(period)-286(of)-279.9(time)-284.5(are)-288.4(lacking,)]TJ
0 -1.1795 TD
[(the)-432.3(clinical)-434.3(evidence)-431.7(summarized)-433.3(here)-435.4(allows)-429.4(to)-429.2(hy-)]TJ
0 -1.1847 TD
-.0001 Tc
[(pothesize)-253.3(that)-249.1(the)-251.3(acceptable)-251.1(dose)-253.9(for)-252.2(supplementation)]TJ
0 -1.1795 TD
0 Tc
[(in)-326.8(adults)-328.1(may)-326.1(be)-325.6(comprised)-323.5(between)-327.4(the)-323.7(total)-324.8(dose)-326.2(of)]TJ
T*
[(510)-168.8(mg/day,)-567(obtained)-569.5(by)-568.1(roughly)-571.3(estimating)-571.2(CBD)]TJ
0 -1.1847 TD
[(exposure)-425.7(through)-425.6(historic)-422.5(use)-427.8(patterns)-427(based)-422(on)-428.2(the)]TJ
0 -1.1795 TD
[(available)-269.4(data)-264.7(on)-267.8(smoked)]TJ
/F6 1 Tf
10.3515 0 TD
(Cannabis)Tj
/F7 1 Tf
8.2191 0 0 7.3052 214.2424 210.6141 Tm
(63)Tj
10.959 0 0 10.959 225.0708 205.7385 Tm
[(and)-266.1(the)-266.8(pharma-)]TJ
-15.085 -1.1847 TD
[(cological)-217(total)-216.2(daily)-216.7(doses)]TJ
/F11 1 Tf
10.3981 0 TD
(>)Tj
/F7 1 Tf
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[(350)-161.5(mg)-219.9(a)-214.8(day,)-219(that)-212.8(is,)-218.5(in)-218.1(the)]TJ
-11.1171 -1.1795 TD
[(range)-241.3(of)-243.6(50100)-162.7(mg)-240.6(a)-245.9(day.)-239.7(This)-243.4(may)-238.1(represent)-244.2(the)-240.9(dose)]TJ
0 -1.1847 TD
[(range)-324.1(for)-319.4(testing)-321.3(CBD)-318.6(hemp)-318(supplements)-319(as)-321.6(part)-317(of)-321.2(a)]TJ
0 -1.1795 TD
[(healthy)-297.9(diet.)]TJ
1.0036 -1.1847 TD
[(The)-497.9(need)-497(for)-500.4(further)-502.2(research)-499.5(is)-498.6(becoming)-499.4(more)]TJ
-1.0036 -1.1795 TD
[(compelling)-320.9(as)-321.6(multinational)-320(companies)-317.5(such)-321.1(as)-321.6(Coca-)]TJ
0 -1.1847 TD
[(Cola)-340.1(are)-345.3(planning)-342.3(to)-341.3(supplement)-341.5(some)-339.4(of)-341.9(their)-341.1(prod-)]TJ
0 -1.1795 TD
[(ucts)-508.7(with)-506.2(CBD,)]TJ
8.2191 0 0 7.3052 131.7543 106.9795 Tm
(64)Tj
10.959 0 0 10.959 145.1905 102.1039 Tm
[(which)-507.9(will)-508.1(expand)-507.2(the)-504.7(variety)-507.2(of)]TJ
-7.796 -1.1795 TD
[(CBD-supplemented)-316.8(food)-315.2(and)-317.8(beveragesas)-315.3(an)-315.3(exam-)]TJ
0 -1.1847 TD
[(ple,)-789.4(a)-789(Californian)-791.4(company)-785.7(is)-788.3(marketing)-789(CBD-)]TJ
0 -1.1795 TD
[(supplemented)-238.4(wine,)]TJ
8.2191 0 0 7.3052 146.8346 68.1449 Tm
(65)Tj
10.959 0 0 10.959 157.3228 63.2692 Tm
[(while)-230.2(New)-237.3(York-based)-231.8(company)]TJ
14.009 57.9085 TD
[(Sovereign)-200.7(Vines)-200(has)-199.3(produced)-202.2(a)-199.3(wine)-201.2(with)-195.8(special)-203(tastes)]TJ
0 -1.1847 TD
[(and)-297.1(avors)-299.9(of)-300.5(hemp.)]TJ
/F4 1 Tf
10.4607 0 0 10.4607 310.8472 658.9983 Tm
[(Hemp)-299.7(Food)]TJ
/F7 1 Tf
10.959 0 0 10.959 310.8472 646.0723 Tm
[(Hemp)-270(has)-276.9(been)-273.9(a)-271.7(valuable)-275.7(source)-275.6(of)-269.5(food)-273.8(for)-278(mankind)]TJ
T*
[(for)-438.3(millennia,)-443.3(as)-440.6(shown)-439.2(by)-438.8(the)-442.6(hempseeds)-441.8(found)-437.1(in)]TJ
0 -1.1795 TD
[(tombs)-543.2(dating)-539.4(back)-548(to)-543(the)-540.9(third)-542.4(millennium)-542.3(before)]TJ
0 -1.1847 TD
[(Christ)-357.9(in)-357.8(China,)-357.5(where)-353.3(roasted)-356.1(hempseed)-360.9(can)-359.7(still)-353.6(be)]TJ
0 -1.1795 TD
[(bought)-587.8(on)-593.7(the)-592.7(street)-593.3(as)-595.8(snacks.)]TJ
8.2191 0 0 7.3052 462.7274 599.1306 Tm
(66)Tj
10.959 0 0 10.959 477.0707 594.2549 Tm
[(Although)-592.4(hemp)]TJ
-15.1677 -1.1847 TD
[(leaves,)-513.9(sprouts,)-515.8(and)-514.4(owers)-515.8(can)-514.9(be)-511.8(consumed)-515.2(as)-518.2(a)]TJ
0 -1.1795 TD
[(raw)-327.4(food)-325.5(by)-330.1(preparing)-325.8(juices)-329.6(and)-328.1(salads,)]TJ
8.2191 0 0 7.3052 490.677 573.2219 Tm
(67)Tj
10.959 0 0 10.959 502.1857 568.3463 Tm
(hempseeds)Tj
-17.4595 -1.1847 TD
[(represent)-414.9(the)-411.6(most)-417.2(common)-412.7(part)-415.2(of)-414.4(the)-411.6(hemp)-416.2(plant)]TJ
0 -1.1795 TD
[(to)-372.3(be)-372.1(consumed)-370.3(as)-373.3(food.)-371.4(The)-373.8(true)-369(seed)-374(is)-374.4(an)-372.2(achene,)]TJ
T*
[(enveloped)-303.3(by)-309.4(a)-307.9(subtle)-301.9(and)-307.4(hard)-310.4(pericarp,)-308(and)-307.5(matures)]TJ
0 -1.1847 TD
[(36)-497.8(weeks)-498.8(after)-497.3(the)-499.5(fertilization)-501.8(of)-497.1(female)-497.4(ower.)]TJ
8.2191 0 0 7.3052 542.0408 521.4046 Tm
(68)Tj
10.959 0 0 10.959 310.8472 503.603 Tm
[(Hempseeds)-342.1(provide)]TJ
/F9 1 Tf
8.3185 0 TD
(*)Tj
/F7 1 Tf
.9984 0 TD
[(500600)-340.7(Kcal/100)-165.7(g)-343.8(o)0(f)-347.1(product)]TJ
-9.3169 -1.1847 TD
[(and)-240.2(are)-236.7(composed)-240.6(of)-238.5(approximately)-236.3(one-fourth)-238.6(of)-238.5(pro-)]TJ
0 -1.1795 TD
[(teins,)-449.4(one-fourth)-450.7(of)-450.6(carbohydrates,)-448.1(and)-452.3(one-third)-448.9(of)]TJ
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T*
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T*
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T*
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(89)Tj
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T*
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(90)Tj
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T*
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(91)Tj
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T*
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[(try,)-299.6(and)-303.9(cheminforma)-13.2(tics.)-299.3(Anal)-306.1(Bioanal)-303.8(Chem.)-305.2(2019;412)-11.7(:423423.)]TJ
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[(21.)-505.4(Cerrato)-303.4(A,)-299.2(Cannazz)-10(a)-302.5(G)0(,)-296.1(Caprio)-11.4(tti)-303.1(A,)-299.2(et)-301(al.)-301.4(A)-298.9(new)-305.6(software-assi)-15.9(sted)-300(ana-)]TJ
1.7224 -1.1988 TD
[(lytical)-305.8(workow)-308.1(based)-301.9(on)-303.1(high-resolution)-310.6(mass)-303.3(spectrometry)-316.1(for)-302.8(the)]TJ
0 -1.2064 TD
[(systematic)-306.8(study)-307(of)-298.6(pheno)-9.4(lic)-301.4(compounds)-307.1(in)-304(complex)-307.3(matrices.)-305.1(Talanta)]TJ
0 -1.1988 TD
(2020;209:120573.)Tj
-1.7224 -1.1988 TD
[(22.)-505.4(Hartsel)-287.3(JA,)-284.2(Eades)-291.4(J,)-288.8(Hickory)-286.9(B,)-286.3(et)-285.8(al.)]TJ
/F13 1 Tf
16.6471 0 TD
[(Cannabis)-295.9(sativa)]TJ
/F10 1 Tf
6.7226 0 TD
[(and)-288.7(hemp.)-284.9(In:)-289.1(Gupta)]TJ
-21.6473 -1.1988 TD
[(RC,)-301(Srivastava)-309.6(A,)-299.2(Lall)-302.2(R.)-303.9(\(eds.\))-303.1(Nutraceuticals)-312.9(in)-304(Veterinary)-306.6(Medicine.)]TJ
T*
[(Springer:)-304.1(Basel,)-307.1(Switzerland,)-304.8(2019,)-304.9(pp.)-310.4(735754.)]TJ
-1.7224 -1.1988 TD
[(23.)-505.4(De)-262.9(Petrocelli)-12.2(s)-265.1(L)0(,)-268.3(Ligresti)-268.5(A,)-268.9(Moriel)-10(lo)-261.9(AS,)-273.1(et)-263(al.)-271.1(Effects)-269.7(of)-268.2(can)-9.2(nabinoids)-269.5(and)]TJ
1.7224 -1.2064 TD
(cannabinoid-enriched)Tj
/F13 1 Tf
9.4617 0 TD
(Cannabis)Tj
/F10 1 Tf
4.0669 0 TD
[(extracts)-306.1(on)-303.1(TRP)-300.4(channels)-307.9(and)-303.9(endocan-)]TJ
-13.5286 -1.1988 TD
[(nabinoid)-300.3(metabo)-10.6(lic)-301.4(enzymes.)-308.8(Br)-297.9(J)-303.7(Pharmacol.)-306.9(2011;163)-11.7(:14791494.)]TJ
/F4 1 Tf
9.9626 0 0 9.9626 59.7543 753.8455 Tm
[(A)-305.3(REVIEW)-309.7(OF)-302.7(HEMP)-303.3(AS)-303.5(FOO)-10.1(D)-297.5(AND)-308.4(SUPPLE)-9.9(MENT)-26180.8(25)]TJ
ET
endstream
endobj
107 0 obj
<>stream
/GS1 gs
BT
/F10 1 Tf
7.4718 0 0 7.4718 62.022 700.2707 Tm
0 0 0 rg
0 Tc
0 Tw
[(24.)-505.4(Di)-283.5(Marzo)-289.6(V,)-290.5(Piscitelli)-286.9(F.)-287.6(The)-287.6(endocannabinoi)-14(d)-280.2(system)-296.6(and)-281.2(its)-290.8(modulation)]TJ
1.7224 -1.2064 TD
[(by)-297.8(phytoca)-13.1(nnabinoids.)-309.7(Neurotherapeutics)-312(2015;12:692)-16.3(698.)]TJ
-1.7224 -1.1988 TD
[(25.)-505.4(Di)-298.7(Marzo)-304.7(V.)-305.7(New)-300.2(approaches)-305.5(an)-8.5(d)-295.4(challeng)-11.1(es)-296.3(to)-305.5(targeting)-305.3(the)-302.9(endocan-)]TJ
1.7224 -1.1988 TD
[(nabinoid)-307.9(system.)-304.5(Nat)-303.3(Rev)-303.5(Drug)-303.9(Discov.)-303.5(2018;17:)-13.6(623639.)]TJ
-1.7224 -1.1988 TD
[(26.)-505.4(Laverty)-308.2(KU,)-301.5(Stout)-304.1(JM,)-306.3(Sullivan)-301.3(MJ,)-306.3(et)-301(al.)-301.4(A)-298.9(physical)-311.5(and)-303.9(genetic)-304.9(map)-303.7(of)]TJ
/F13 1 Tf
1.7224 -1.1988 TD
[(Cannabis)-257.9(sativa)]TJ
/F10 1 Tf
6.6543 0 TD
[(identies)-258(extensive)-261(rearrangements)-259.7(at)-253.7(the)-257.4(THC/CBD)-259(acid)]TJ
-6.6543 -1.1988 TD
[(synthase)-305.4(loci.)-307(Genome)-306.3(Res.)-304.3(2019;29:146156.)]TJ
-1.7224 -1.2064 TD
[(27.)-505.4(Jones)-250.6(NA,)-257.8(Hill)-246.2(AJ,)-253.9(Smith)-253.5(I,)-249.3(et)-255.4(al.)-248.3(Cannabidiol)-257.1(displa)-10(ys)-244.8(an)-8.5(tiepileptiform)-255(and)]TJ
1.7224 -1.1988 TD
[(antiseizure)-307(properties)-312.8(in)-296.4(vitro)-307.4(and)-303.9(in)-296.4(vivo.)-305.8(J)-303.7(Pharmacol)-306.6(Exp)-304.4(Ther.)-299.8(2010;)]TJ
T*
(332:569577.)Tj
-1.7224 -1.1988 TD
[(28.)-505.4(Sun)-299.7(Y,)-296.3(Dolmetsch)-297.7(RE.)-300.5(Erratum:)-304(investigating)-306.4(the)-295.3(therapeutic)-300.2(mechanis)-11.7(m)]TJ
1.7224 -1.1988 TD
[(of)-298.6(canna)-10.1(bidiol)-303.7(in)-296.4(a)-302.5(human)-305.7(induced)-302.2(pluripotent)-310.7(stem)-309.8(cell)-302.2(\(iPSC\)-based)]TJ
T*
[(model)-286.6(of)-291(Dravet)-292.3(syndrome.)-296.5(Cold)-288.8(Spring)-291.1(Harb)-291.1(Symp)-288.5(Quant)-287.2(Biol.)-288.9(2018;83)-13.3(:)]TJ
T*
(038919.)Tj
-1.7224 -1.2064 TD
[(29.)-505.4(Campos)-305.6(AC,)-303.9(Ortega)-302.1(Z,)-305.7(Palazuelos)-307.9(J,)-304(et)-301(al.)-301.4(The)-302.8(anxiolytic)-302.7(effect)-312.3(of)-298.6(canna-)]TJ
1.7224 -1.1988 TD
[(bidiol)-296.1(on)-287.9(chronica)-12.4(lly)-288(stressed)-304.2(mice)-290.1(depend)-9.5(s)-287.9(o)0(n)-295.5(hippocampal)-299.3(neurogen-)]TJ
T*
[(esis:)-302.3(involvement)-307.9(of)-306.1(the)-302.9(endocannabinoid)-309.4(system.)-304.5(Int)-308.3(J)]TJ
T*
[(Neuropsycho)-14.1(pharmacol.)-306.2(2013;16:1407)-14.7(1419.)]TJ
-1.7224 -1.1988 TD
[(30.)-505.4(Costa)-301.2(B,)-309.1(Colleoni)-302.2(M,)-306.1(Conti)-303.1(S,)-300.4(et)-301(al.)-301.4(Oral)-308.9(anti-inammatory)-307.9(acti)-10.2(vity)-300.3(of)]TJ
1.7224 -1.1988 TD
[(cannabidiol,)-306.5(a)-302.5(non-psycho)-12.4(active)-305.9(constituent)-307.7(of)]TJ
/F13 1 Tf
19.9932 0 TD
[(cannab)-12.3(is)]TJ
/F10 1 Tf
3.6344 0 TD
[(,)-296.2(i)0(n)-304(acute)]TJ
-23.6276 -1.2064 TD
[(carrageenan-indu)-12.9(ced)-304.5(inammation)-303.9(in)-304(the)-302.9(rat)-303.5(paw.)-301.7(Naunyn)-303(Schmiede-)]TJ
0 -1.1988 TD
[(bergs)-301.9(Arch)-305.8(Pharmacol.)-306.9(2004;369)-11.7(:294299.)]TJ
-1.7224 -1.1988 TD
[(31.)-505.4(Pertwee)-306.4(RG.)-303.9(The)-302.8(diverse)-306.1(CB1)-304.3(and)-296.3(CB2)-304.3(receptor)-308.2(pharmacolo)-15.3(gy)-300.2(of)-298.6(three)]TJ
1.7224 -1.1988 TD
[(plant)-299.2(can)-9.2(nabinoids:)-307.8(delta9-tetrahydr)-15.3(ocannabinol,)-308(cannabidiol)-306.3(and)]TJ
T*
[(delta9-tetrahydr)-15.3(ocannabivarin.)-312.6(Br)-297.9(J)-303.7(Pharmacol.)-306.9(2008;153)-11.7(:199215.)]TJ
-1.7224 -1.1988 TD
[(32.)-505.4(Walter)-302.2(L,)-306.2(Franklin)-301.8(A,)-306.8(Witting)-304.8(A,)-299.2(et)-301(al.)-301.4(Nonp)-10.8(sychotropic)-310.9(cannabinoid)-309.5(re-)]TJ
1.7224 -1.2064 TD
[(ceptors)-219.2(regul)-10.9(ate)-216.5(microglial)-219.8(cell)-218.8(migration.)-228.4(J)-212.7(Neuros)-11.8(ci.)-219.6(2003;23:13981405)-16.6(.)]TJ
-1.7224 -1.1988 TD
[(33.)-505.4(McHugh)-247.3(D,)-247.2(Tanner)-239.7(C,)-247.7(Mechoulam)-250.8(R,)-243.2(et)-240.3(al.)-248.3(Inhibition)-244.5(of)-245.4(human)-245(neutrophil)]TJ
1.7224 -1.1988 TD
[(chemotaxis)-305(by)-305.4(endogeno)-9.8(us)-300.8(cannabinoids)-309.1(and)-303.9(phytocannabino)-13.7(ids:)]TJ
T*
[(evidence)-305.6(for)-302.8(a)-302.5(site)-299.2(distinct)-310.9(from)-304.5(CB1)-304.3(and)-303.9(CB2.)-304.6(Mol)-302.2(Pharmacol.)-306.9(2008;73:)]TJ
T*
(441450.)Tj
-1.7224 -1.1988 TD
[(34.)-505.4(Poupot)-308.2(R,)-296.3(Bergo)-10(zza)-298.3(D,)-300.3(Fruch)-11.2(on)-295.5(S.)-308(Nanoparticle-based)-312(strategies)-309(to)-305.5(treat)]TJ
1.7224 -1.1988 TD
[(neuro-inammat)-13.7(ion.)-302(Materials)-310(\(Basel\))-298.7(2018;11)-13.3(:pii:E270.)]TJ
-1.7224 -1.2064 TD
[(35.)-505.4(Kozela)-302.9(E,)-300.4(Lev)-305.8(N,)-300.3(Kaushans)-11.6(ky)-300.8(N,)-300.3(et)-301(al.)-301.4(Cannabid)-11.7(iol)-298.5(inhibits)-306.5(pathogenic)-309.8(T)]TJ
1.7224 -1.1988 TD
[(cells,)-302.1(decreas)-12.2(es)-296.3(spinal)-308.3(microglial)-303.3(activat)-12.5(ion)-301.8(and)-296.3(am)-8.2(eliorates)-307.2(multiple)]TJ
T*
[(sclerosis-like)-312.5(disease)-301.4(in)-304(C57BL/6)-304.3(mice)-9.3(.)-296.2(B)0(r)-305.5(J)-296.1(Pha)-8.7(rmacol.)-305.8(2011;163:1507)]TJ
T*
(1519.)Tj
-1.7224 -1.1988 TD
[(36.)-505.4(Ligresti)-306.4(A,)-299.2(Moriel)-9.9(lo)-299.9(AS,)-303.4(Starowicz)-309.7(K,)-301.5(et)-301(al.)-301.4(Antitumor)-309.4(activity)-302.9(of)-306.2(plant)]TJ
1.7224 -1.1988 TD
[(cannabinoids)-309.1(with)-300.1(emp)-9.5(hasis)-302.2(on)-303.1(the)-302.9(effect)-304.7(of)-298.6(cannab)-9.6(idiol)-296.6(on)-303.1(hum)-8.9(an)]TJ
0 -1.2064 TD
[(breast)-303.3(carcinom)-12.2(a.)-302.8(J)-296.1(Pharmaco)-12(l)-294.5(Exp)-304.4(Ther.)-307.4(2006;318:1375138)-16.6(7.)]TJ
-1.7224 -1.1988 TD
[(37.)-505.4(Takahashi)-309.2(N,)-300.3(Chen)-305.2(HY,)-303.9(Harris)-301.6(IS,)-306.6(et)-301(al.)-301.4(Cancer)-307.3(cells)-301.8(co-opt)-304.9(the)-302.9(neuronal)]TJ
1.7224 -1.1988 TD
[(redox-sensing)-308.8(channel)-308.3(trpa1)-301.4(to)-305.5(promote)-309.4(oxidative-stress)-307.9(tolerance.)]TJ
T*
[(Cancer)-307.3(Cell)-298.6(2018;33:985)-16.3(1003.e7.)]TJ
-1.7224 -1.1988 TD
[(38.)-505.4(Romano)-301.7(B,)-301.5(Borr)-11.6(elli)-300.2(F,)-302.8(Fasolino)-303.3(I,)-302.4(et)-301(al.)-301.4(The)-302.8(cannabin)-10.2(oid)-299.3(TRPA1)-301.8(agonist)]TJ
1.7224 -1.1988 TD
[(cannabichromene)-313.9(inhibits)-306.5(nitric)-304.3(oxide)-305(production)-305.4(in)-304(macrophages)-309.6(and)]TJ
T*
[(ameliorates)-307.9(murine)-308.5(colitis.)-301.9(Br)-305.5(J)-303.7(Pharmacol.)-306.9(2013;169:213)-14.7(229.)]TJ
-1.7224 -1.2064 TD
[(39.)-505.4(Borrelli)-304.2(F,)-302.8(Fasolino)-303.3(I,)-302.4(Romano)-309.3(B,)-301.5(et)-301(al.)-301.4(Benecia)-10.7(l)-294.5(effect)-312.3(of)-298.6(the)-302.9(non-)]TJ
1.7224 -1.1988 TD
[(psychotropic)-310.4(plant)-306.8(cannabinoid)-309.5(cannabigerol)-307.5(on)-303.1(experimental)-311(inam-)]TJ
T*
[(matory)-305.3(bowel)-307.2(disease.)-301.6(Biochem)-310.2(Pharmacol.)-306.9(2013;85:1306)-14.7(1316.)]TJ
-1.7224 -1.1988 TD
[(40.)-505.4(Colasanti)-307(BK.)-306.8(A)-298.9(comparison)-311.8(of)-298.6(the)-302.9(ocular)-309.2(and)-296.3(centr)-11.9(al)-293.6(effects)-311.8(of)]TJ
/F12 1 Tf
28.4381 0 TD
(d)Tj
/F10 1 Tf
.5008 0 TD
(9-)Tj
-27.2165 -1.1988 TD
[(tetrahydrocannabino)-18.8(l)-294.5(a)0(n)-8.5(d)-295.4(cannab)-9.6(igerol.)-305.7(J)-296.1(Ocul)-304(Pharmaco)-12(l.)-302.4(1990;6:259)]TJ
T*
(269.)Tj
-1.7224 -1.2064 TD
[(41.)-505.4(Runo)-297(AT,)-288.2(Ribeiro)-295.6(M,)-290.9(Sousa)-301.7(C,)-293.3(et)-285.8(al.)-293.9(Evaluation)-296.1(of)-298.6(the)-287.7(anti-inamm)-11.8(atory,)]TJ
1.7224 -1.1988 TD
[(anti-catabolic)-307(an)-8.5(d)-295.4(pro-ana)-10.5(bolic)-298.7(effects)-311.9(of)-298.6(E-caryophy)-13.7(llene,)-304.5(myrcene)-300.9(an)-8.5(d)]TJ
T*
[(limonene)-305.5(in)-296.4(a)-302.5(cell)-302.2(model)-309.4(of)-298.6(osteoarthr)-13.8(itis.)-304.9(Eur)-302.1(J)-296.1(Pha)-8.7(rmacol.)-305.8(2015;750:)]TJ
T*
(141150.)Tj
-1.7224 -1.1988 TD
[(42.)-505.4(Jansen)-306.9(C,)-300.9(Shimoda)-306.1(LM,)-300.9(Kawakami)-308.1(JK,)-301.7(et)-301(al.)-301.4(Myrce)-10.5(ne)-298.6(and)-303.9(terpene)-300.6(regu-)]TJ
1.7224 -1.1988 TD
[(lation)-303.7(of)-298.6(TRPV1.)-308.6(Channels)-304.3(\(Austin\))-308.1(2019;13:3443)-15.5(66.)]TJ
-1.7224 -1.1988 TD
[(43.)-505.4(Hirota)-307.4(R,)-296.3(Roger)-308.3(NN,)-304.5(Nakamura)-303.2(H,)-303.7(et)-301(al.)-301.4(Ant)-9.2(i-inammatory)-310.2(effects)-304.3(of)-306.2(lim-)]TJ
1.7224 -1.2064 TD
[(onene)-230.7(from)-236.2(Yuzu)-228.7(\()]TJ
/F13 1 Tf
7.6482 0 TD
[(Citrus)-233.5(junos)]TJ
/F10 1 Tf
4.9016 0 TD
[(Tanaka\))-233(essential)-238.4(oil)-230.2(on)-227.2(eosinophils.)-237.7(J)-227.8(Food)]TJ
-12.5498 -1.1988 TD
[(Sci.)-299.7(2010;75)-13.3(:H87H92.)]TJ
-1.7224 -1.1988 TD
[(44.)-505.4(Hirota)-307.4(R,)-296.3(Nakamu)-11.6(ra)-299.2(H,)-303.7(Bhatti)-301.8(SA,)-303.4(et)-301(al.)-309(Limonene)-301.8(inhalati)-9.6(on)-295.5(redu)-9.9(ces)-296.9(al-)]TJ
1.7224 -1.1988 TD
[(lergic)-300.8(airway)-306.3(inammatio)-13.7(n)-297.8(i)0(n)]TJ
/F13 1 Tf
12.5574 0 TD
[(Dermatophagoides)-317.4(farinae)]TJ
/F10 1 Tf
10.8729 0 TD
[(-treated)-302.7(mice.)]TJ
-23.4303 -1.1988 TD
[(Inhal)-303.6(Toxicol.)-306.2(2012;24:3733)-15.5(81.)]TJ
-1.7224 -1.1988 TD
[(45.)-505.4(Bahi)-255.3(A,)-261.3(Al)-252(Mansouri)-266.7(S,)-254.9(Al)-259.6(Memari)-257.1(E,)-254.9(et)-255.4(al.)]TJ
/F12 1 Tf
18.6957 0 TD
(b)Tj
/F10 1 Tf
.5463 0 TD
[(-ca)-8.8(ryophyllene,)-259.7(a)-257(CB2)-258.7(receptor)]TJ
-17.5196 -1.2064 TD
[(agonist)-306.5(produces)-310.8(multiple)-303.3(behavioral)-309.6(changes)-301.7(relevant)-304.6(to)-305.5(anxiety)-307.8(and)]TJ
0 -1.1988 TD
[(depression)-305.7(in)-304(mice.)-305.5(Physiol)-302.5(Behav.)-309.9(2014;135:119124.)]TJ
-1.7224 -1.1988 TD
[(46.)-505.4(Barrett)-303(ML,)-308.5(Scutt)-307.1(AM,)-301.5(Evans)-299.6(FJ.)-303(Cann)-11.1(avin)-302.1(A)-298.9(and)-303.9(B,)-301.5(prenylated)-307(avones)]TJ
1.7224 -1.1988 TD
(from)Tj
/F13 1 Tf
2.2914 0 TD
[(Cannabis)-311(sativa)]TJ
/F10 1 Tf
6.7529 0 TD
[(L.)-298.6(Experient)-11.6(ia)-301.1(1986;42:452453.)]TJ
-10.7667 -1.1988 TD
[(47.)-505.4(Werz)-305.7(O,)-299.7(Seegers)-308.2(J,)-296.4(Schaib)-11.5(le)-295.3(AM,)-301.5(et)-308.6(al.)-301.4(Cannavins)-305.1(from)-304.5(hemp)-307.3(sprouts,)-306.4(a)]TJ
1.7224 -1.1988 TD
[(novel)-301.6(cannab)-9.6(inoid-free)-304.6(hemp)-299.7(food)-311(product,)-307.5(target)-302.9(microsomal)-310.7(prosta-)]TJ
33.5976 84.0017 TD
[(glandin)-305(E2)-306.1(synthase-1)-305.3(and)-303.9(5-lipoxygenas)-12.5(e.)-297(PharmaN)-10.2(utrition)-303.4(2014;2:)]TJ
0 -1.2064 TD
[(5360)-9.5(.)]TJ
-1.7224 -1.1988 TD
[(48.)-505.4(Devinsky)-297.3(O,)-284.5(Cross)-294.1(JH,)-288.8(Laux)-292.4(L,)-283.5(et)-293.4(al.)-286.3(Trial)-285.5(of)-291(cannabidiol)-291.1(for)-295.2(drug-resistant)]TJ
1.7224 -1.1988 TD
[(seizures)-310.3(in)-296.4(the)-302.9(Dravet)-307.4(syndrome.)-311.6(N)-300(Engl)-302.6(J)-303.7(Med.)-298.8(2017;376)-11.7(:20112020.)]TJ
-1.7224 -1.1988 TD
[(49.)-505.4(Thiele)-217.4(EA,)-212.4(Marsh)-219.5(ED,)-213.5(French)-213.4(JA,)-216(et)-209.9(al.)-218(Cannabidiol)-219.2(in)-213(patients)-212.8(with)-216.7(seizures)]TJ
1.7224 -1.1988 TD
[(as)16.6(s)15.6(o)0(c)16.8(i)16.6(at)19.5(ed)-273.4(wi)17.1(th)-271.7(Le)19.5(nn)19(ox)27.8(-G)21.3(as)16.6(ta)27.1(ut)-282.7(s)15.6(y)0(n)18.4(d)15.7(ro)20.8(me)-283.2(\()15.4(G)0(W)16(P)15(CA)22.7(RE)18.4(4)16.8(\))0(:)-280.8(a)-287.3(ra)19.5(nd)21.4(om)23.4(is)24.6(ed)22.5(,)]TJ
T*
[(do)18(ub)25.6(le)23.3(-b)21.8(li)17.9(nd)29(,)-212.7(p)15.7(la)25.1(ce)21.3(bo)18(-c)20.6(on)23.1(tr)21.8(ol)26.4(le)23.4(d)-211.9(p)15.7(ha)21.8(se)-197.6(3)-203.2(t)0(r)21.8(i)0(a)17.5(l)16.5(.)-205.1(L)0(a)21.3(n)0(c)20.2(e)0(t)-194.7(2)0(0)18.4(1)16.8(8;)16.5(3)16.8(9)0(1)18.4(:)14.9(10)18.4(85)26(1)16(0)16.8(9)0(6)18.4(.)]TJ
-1.7224 -1.2064 TD
[(50.)-505.4(Crippa)-301.5(JA,)-291.8(Guimara)]TJ
9.3554 .0152 TD
()Tj
.387 -.0152 TD
[(es)-296.3(FS,)-291.8(Campos)-298(AC,)-296.3(et)-293.4(al.)-293.9(translational)-302.8(investigation)-302.2(of)]TJ
-8.02 -1.1988 TD
[(the)-302.9(therapeutic)-300.2(pote)-9.9(ntial)-298.4(of)-298.6(cannabidiol)-306.3(\(CBD\):)-302.2(toward)-300.1(a)-294.9(new)-298(age.)-297.9(Front)]TJ
T*
[(Immunol.)-309.3(2018;9:2009.)]TJ
-1.7224 -1.1988 TD
[(51.)-505.4(Taylor)-309.8(L,)-298.6(Gidal)-306.8(B,)-301.5(Blakey)-304.6(G,)-303.7(et)-301(al.)-301.4(A)-298.9(phase)-304.3(I,)-302.4(rando)-10(mized,)-302.3(double-blind,)]TJ
1.7224 -1.1988 TD
[(placebo)-11(-controlled,)-226(single)-213.9(ascending)-223.9(dose,)-217.9(mult)-9.9(iple)-217.6(dose,)-217.9(and)-212.9(food)-219.9(effect)]TJ
T*
[(trial)-308.3(of)-298.6(the)-302.9(safety,)-307.2(tolerability)-310.3(and)-303.9(pharmacokinetics)-314.2(of)-298.6(highly)-308.9(puried)]TJ
T*
[(cannab)-9.6(idiol)-304.2(in)-296.4(healthy)-304.9(subjects)-13.5(.)-296.2(CNS)-308.9(Drugs)-303.5(2018;32:10531067)-16.6(.)]TJ
-1.7224 -1.2064 TD
[(52.)-505.4(EPIDIOL)-11.7(EX)]TJ
/F11 1 Tf
5.6038 0 0 4.9805 358.4125 578.0408 Tm
()Tj
/F10 1 Tf
7.4718 0 0 7.4718 362.8345 574.6959 Tm
[(.)-303.8(https://www.acc)-18(essdata.fda.gov/drugsatfd)-23.6(a_docs/label)]TJ
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[(/2018/)-10.4(210365lbl.pdf)-309.9(Accessed)-308.1(November)-303.8(3,)-302.2(2019.)]TJ
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[(53.)-505.4(Ewing)-302(EL,)-310.4(Skinner)-302.5(MC,)-303.2(Quick)-306.5(MC,)-303.2(et)-301(al.)-301.4(Hepatotoxi)-14.4(city)-301.9(of)-298.6(a)-302.5(cannabidio)-11.7(l-)]TJ
1.7224 -1.1988 TD
(rich)Tj
/F13 1 Tf
1.859 0 TD
(Cannabis)Tj
/F10 1 Tf
4.0593 0 TD
[(extract)-306.5(in)-304(the)-302.9(mouse)-301(model.)-309.7(Molecules)-307.9(2019;24:pii:E169)-17.6(4.)]TJ
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[(54.)-505.4(Kight)-270(R.)-266(The)-272.5(HIA)-267.2(v.)-264.9(DEA)-269.3(ruling)-268.6(and)-266(a)-272.2(Wisconsin)-271(policy)-270.7(underlin)-10.9(e)-266.3(need)-260.9(for)]TJ
1.7224 -1.1988 TD
[(clarity)-311.5(on)-295.5(CBD.)-310.3(2018.)-304.9(Available)-299.8(at)-306.8(https://canna)-14.1(business.law/a-tough-)]TJ
0 -1.2064 TD
[(week-f)-9.9(or-cbd-the-hia-v-d)-14.3(ea-ruling-and-a-wisc)-14.3(onsin-policy-underline-)]TJ
0 -1.1988 TD
[(need-f)-9.4(or-clarity/)-308.2(Accessed)-308.1(November)-303.8(3,)-302.2(2019.)]TJ
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[(55.)-505.4(Europ)-11(ean)-221.7(Commission.)-229.6(EU)-224.2(novel)-218.1(food)-227.5(catalogue)-227.4(\(v.1.1\).)-223.7(201)-10.3(9.)-218.7(Available)-223.9(at)]TJ
1.7224 -1.1988 TD
[(http://)-11.9(ec.europa.eu/food/saf)-19.9(ety/novel_food/ca)-15.3(talogue/search/publi)-17.2(c/)]TJ
T*
[(index.cf)-11.6(m)-297.5(Accessed)-308.1(Novemb)-10.4(er)-301(20,)-300.5(2019.)]TJ
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[(56.)-505.4(Cannabis)-307.7(Pharma.)-309.8(Summary)-306.9(of)-298.6(the)-302.9(dossie)-10.9(r:)-300.5(\()]TJ
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20.365 0 TD
()Tj
/F10 1 Tf
.7739 0 TD
[(\)-trans-cannabidiol)-310.5(appli-)]TJ
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[(cant.)-264.1(2019.)-267(Availabl)-10.7(e)-258.8(at.)-261.6(https://ec.eur)-16.1(opa.eu/food/sites/f)-20.4(ood/les/safety/)]TJ
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[(docs/nov)-12.2(el-food_sum_ongo)-15.8(ing-app_2018-0349.)-14.4(pdf)-239.1(Accessed)-247.4(November)]TJ
T*
[(30,)-308.1(2019.)]TJ
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[(57.)-505.4(The)-295.2(Brighteld)-291.9(Team.)-294.3(Hemp-derived)-294.2(CBD)-294.8(market)-293.2(to)-290.3(reach)-295($22)-291(billion)-289.6(by)]TJ
1.7224 -1.1988 TD
[(2022.)-304.9(2019.)-304.9(Availabl)-10.7(e)-296.7(a)0(t)-299.2(https://br)-15.3(ighteldgroup.co)-16.6(m/post/hemp-cbd-)]TJ
T*
[(market-to-r)-14.2(each-22-billion-)-12.5(by-2022)-300.5(Access)-11.9(ed)-296.2(Nove)-9.3(mber)-302.1(3,)-302.2(2019.)]TJ
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[(58.)-505.4(Bonn-M)-10.7(iller)-296.9(MO,)-302(Loin)-307.8(MJE,)-302.9(Thomas)-307.6(BF,)-300.5(et)-301(al.)-309(Labeling)-298.7(accuracy)-315.6(of)-298.6(can-)]TJ
1.7224 -1.2064 TD
[(nabidio)-10.1(l)-294.5(extracts)-313.6(sold)-298.9(online.)-311(JAMA)-296.9(2017;31)-13.3(8:17081709.)]TJ
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[(59.)-505.4(Corroon)-220.8(J,)-220.5(Kight)-216.9(R.)-212.9(Regulat)-10.1(ory)-216.9(status)-216.9(of)-215.1(can)-9.2(nabidiol)-213.6(in)-220.6(the)-211.8(United)-217.5(States)-12.1(:)-212.7(a)]TJ
1.7224 -1.1988 TD
[(perspec)-12.7(tive.)-298.9(Cannabis)-307.7(Cannabinoid)-305.9(Re)-8.5(s.)-295.8(2018;3:1)-13.6(90194.)]TJ
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[(60.)-505.4(Corroon)-311.8(J,)-304(Phillips)-299.1(JA.)-307(A)-298.9(cross-secti)-14.8(onal)-300.8(study)-307(of)-298.6(cannab)-9.6(idiol)-304.2(users.)-305.7(Can-)]TJ
1.7224 -1.1988 TD
[(nabis)-302.1(Cannabi)-12.2(noid)-301.3(Res.)-304.3(2018;3:152161.)]TJ
-1.7224 -1.1988 TD
[(61.)-505.4(Deabold)-234.5(AK,)-221.1(Schwark)-232(SW,)-231.4(Wolf)-228.1(L,)-222.8(et)-232.7(al.)-225.6(Single-dose)-232.8(pharmacokinetics)-238.3(and)]TJ
1.7224 -1.2064 TD
[(prelimina)-10.6(ry)-211.6(safety)-223.5(assessment)-219.1(with)-216.7(use)-218.1(of)-215.1(CBD-rich)-218.4(hemp)-216.3(nutraceutica)-16.6(l)-211.1(i)0(n)]TJ
0 -1.1988 TD
[(healthy)-304.9(dogs)-309.8(and)-296.3(cats.)-307.3(Animals)-305.9(\(Basel\))-306.3(2019;9:pii:E8)-14.8(32.)]TJ
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[(62.)-505.4(Patricia)-12.3(n)-297.8(A)0(,)-299.2(Versic-B)-12.7(ratincevic)-303.8(M,)-306.1(Mijacika)-300.5(T,)-308(et)-301(al.)-301.4(Examination)-307.7(of)-298.6(a)-302.5(new)]TJ
1.7224 -1.1988 TD
[(delivery)-254.5(appr)-9.9(oach)-249.7(for)-249.7(oral)-257.6(cannabidiol)-253.1(in)-250.9(healthy)-259.4(subjects:)-256.6(a)-249.4(randomized,)]TJ
T*
[(double-)-10.6(blinded,)-302.2(placebo)-11(-controlled)-309.1(pharmacokinetics)-314.2(study.)-307.3(Adv)-297.5(Ther.)]TJ
T*
[(2019;36:)-13.6(31963210.)]TJ
-1.7224 -1.1988 TD
[(63.)-505.4(Cogan)-225.3(PS.)-217.1(On)-217.8(healthcare)-223.8(by)-214.4(popular)-224(appeal:)-224.4(critical)-224.9(assessment)-219.2(of)-222.7(benet)]TJ
1.7224 -1.2064 TD
[(and)-303.9(risk)-300.8(in)-304(cannabidio)-11.7(l)-294.5(based)-309.4(dietary)-304.8(supplement)-11.9(s.)-295.8(Ex)-9(pert)-297.1(Rev)-303.5(Clin)]TJ
0 -1.1988 TD
[(Pharmaco)-12(l.)-302.4(2019;12:501511.)]TJ
-1.7224 -1.1988 TD
[(64.)-505.4(Skerritt)-311.5(J)-296.1(and)-303.9(Giammona)-310.7(C.)-300.9(Coca-Col)-12.2(a,)-295.2(Auro)-10.3(ra)]TJ
/F13 1 Tf
21.321 0 TD
(Cannabis)Tj
/F10 1 Tf
4.0669 0 TD
[(in)-296.4(talks)-307.4(about)]TJ
-23.6655 -1.1988 TD
[(CBD)-302.4(oil)-306.1(soda)-306.9()-296.7(Bloomberg.)-311.3(2018.)-304.9(Available)-307.4(at)-299.2(https://www.bl)-15.8(oomberg)]TJ
T*
[(.com/ne)-11.5(ws/articles/2018)-15.3(-09-17/coca-cola-eyes-cann)-18.4(abis-market-in-)-14.2(push-)]TJ
T*
[(beyon)-9.9(d-sluggish-sodas)-308.8(Access)-11.9(ed)-296.2(Novemb)-10.4(er)-301(30,)-300.5(2019.)]TJ
-1.7224 -1.2064 TD
[(65.)-505.4(Ba)18.4(rr)21.8(on)23.1(s)-219.6(C)0(.)-217.4(4)-218.4(ca)15.5(nn)26.6(ab)24.3(is)17(-i)22.6(nf)23.5(us)25.5(ed)-212.7(wi)24.7(ne)20.1(s)-227.2(w)15.8(or)20.8(th)-211(bu)18(yi)21.7(ng)26.6(.)-227.9(2)16.8(01)18.4(8.)-211.1(Av)20.7(a)16.2(i)0(l)17.9(a)16.2(bl)17.1(e)-220.8(a)16.2(t)-224.3(h)0(t)16.6(t)0(p)26.6(s)0(:)]TJ
1.7224 -1.1988 TD
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T*
[(bi)17.1(s)15.6(-)0(m)19.6(a)16.2(rk)16.1(et)25.3(-i)22.6(n-)19.4(p)15.7(u)0(s)17.9(h)0(-)26.9(b)0(e)22.5(y)0(o)22.6(n)0(d)21.4(-)0(s)21.7(l)0(u)18.8(g)0(g)26.6(i)0(s)17(h)0(-)26.9(s)0(o)17.9(d)15.7(as)-279.3(Ac)19.1(c)14.5(e)0(s)22.4(s)0(e)22.4(d)-287.8(No)20.9(ve)23(mb)21.6(er)-278.2(30)18.4(,)-288.6(2)0(0)26(1)0(9)18.4(.)]TJ
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[(66.)-505.4(Li)-304.6(HL.)-306.2(The)-295.2(or)-9.6(igin)-297(and)-303.9(use)-301.6(of)]TJ
/F13 1 Tf
13.6803 0 TD
(Cannabis)Tj
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[(implicatio)-12.6(ns.)-297.7(Eco)-10.2(n)-297.8(Bot.)-303.5(1974;28:2933)-15.5(01.)]TJ
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/F13 1 Tf
1.7224 -1.1988 TD
(Cannabis.)Tj
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4.2718 0 TD
[(2017.)-304.9(Ava)-8.7(ilable)-298.7(at)-306.8(https://www.royalquee)-18.6(nseeds.com/blog-)]TJ
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[(the-thera)-11.2(peutic-and-dietary-)-15.5(benets-of-eating)-15(-raw-cannabis-n51)-13.7(7)]TJ
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[(68.)-505.4(Chandr)-11.3(a)-294.9(S)0(,)-308(Lata)-300.7(H,)-303.7(ElSohly)-303.7(MA.)]TJ
/F13 1 Tf
14.9399 0 TD
[(Cannabis)-311(sativa)]TJ
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6.7529 0 TD
[(L.bota)-12.4(ny)-300.2(and)]TJ
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[(biotech)-11.1(nology.)-304.1(New)-300.3(York:)-308.4(Springer,)-304.1(2017.)]TJ
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1.7224 -1.1988 TD
[(dietary)-304.8(hemps)-11(eed.)-297.3(Nutr)-306.3(Metab)-309.4(\(Lond\).)-304.8(2010;7:32.)]TJ
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[(70.)-505.4(Irakli)-267.2(M,)-253(Tsaliki)-266.7(E,)-262.5(Kalivas)-257.2(A,)-261.3(et)-263(al.)-255.9(Effect)-262.6(of)-260.6(genotype)-267.3(and)-258.4(growing)-263.7(year)-264.5(on)]TJ
1.7224 -1.1988 TD
[(the)-302.9(nutritional,)-310.8(phytochemical)-15.4(,)-296.2(and)-303.9(antioxida)-11.2(nt)-302.1(properties)-305.2(of)-306.2(industrial)]TJ
T*
[(hemp)-307.3(\()]TJ
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[(Cannabis)-303.4(sat)-10.4(iva)]TJ
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6.7529 0 TD
[(L.\))-298.4(seeds.)-311.6(Antioxidants)-309.2(\(Basel\))-306.3(2019;8:pii:E491.)]TJ
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[(71.)-505.4(Aluko)-212(RE.)-201.9(Hem)-10(p)-204.3(seed)-205.5(\()]TJ
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10.9336 0 TD
[(Cannabis)-212.4(sativa)]TJ
/F10 1 Tf
6.5632 0 TD
[(L.\))-199.7(protei)-12.8(ns:)-206.6(composition,)-210.8(structure,)]TJ
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T*
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/F4 1 Tf
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42.7246 0 TD
[(CERINO)-310.1(ET)-299.4(AL.)]TJ
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1.7224 -1.2064 TD
[(sion.)-309.2(2019.)-304.9(Available)-299.8(at)-306.8(https://clinicaltrials.)-20.6(gov/ct2/show/NCT)-16.2(03508895)]TJ
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T*
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[(74.)-505.4(Si)19.9(a)16.2(n)0(o)-280.4(F)0(,)-280(M)0(o)22.7(c)14.5(ci)15.9(a)-287.3(S)0(,)-277.6(P)15(ic)15.9(a)16.2(r)0(i)19.9(e)0(l)23.3(l)0(o)-277.1(G)0(,)-281(e)0(t)-278.2(a)16.2(l.)-279.6(Co)20.4(mp)21.6(a)16.2(r)0(a)19.5(t)0(i)19.9(v)16.2(e)-289.1(s)0(t)18.9(u)0(d)18(y)-283.2(of)-283.4(c)14.5(h)0(e)20.1(m)0(i)22.5(c)14.5(al)17.5(,)-288.6(b)15.7(io)18.8(-)]TJ
1.7224 -1.2064 TD
[(ch)20.2(em)20.3(i)16.5(c)0(a)23.1(l)-271.8(c)14.5(h)0(a)21.8(r)0(a)19.5(c)14.5(te)17.7(ri)19.9(s)15.6(t)0(i)19.9(c)-266.2(an)21.8(d)-265(A)0(T)15.6(R)15(-F)22.2(TI)19.9(R)-265.7(A)0(n)25.4(a)0(l)17.5(y)0(s)20.8(i)16.6(s)-272.7(o)0(f)-253(s)0(e)22.4(e)0(d)22.5(s)0(,)-257.8(o)0(i)18.8(l)-264.2(an)21.8(d)-265()0(o)21.5(u)0(r)-260(o)0(f)-260.6(t)0(h)24.2(e)]TJ
0 -1.1988 TD
[(ed)22.5(ib)24.7(le)-280.1(Fe)23(do)18(ra)-276.4(c)14.5(u)0(l)18.8(t)0(i)27.5(v)0(a)17.1(r)-285(he)20.1(mp)-274.3(\()]TJ
/F13 1 Tf
12.1628 0 TD
[(Ca)24.9(nn)22.5(ab)15.7(is)-275.4(sa)19(t)16.1(i)0(v)20.1(a)]TJ
/F10 1 Tf
6.586 0 TD
[(L.)20(\))15.4(.)-288.6(Mo)22.7(le)23.4(cu)16.8(l)16.5(e)0(s)-281.1(2)0(0)26(1)0(8)18.4(;)14.9(24)18.4(:8)24.1(3.)]TJ
-20.4712 -1.1988 TD
[(75.)-505.4(Pojic)]TJ
3.3537 .0304 TD
()Tj
.5767 -.0304 TD
[(M,)-207.4(Dap)]TJ
/F14 1 Tf
2.8833 .0304 TD
()Tj
/F15 1 Tf
.0228 -.0304 TD
(c)Tj
/F10 1 Tf
.4477 0 TD
(evic)Tj
1.2975 .0304 TD
()Tj
.5767 -.0304 TD
(Hadna)Tj
/F16 1 Tf
2.7239 0 TD
(C)Tj
/F10 1 Tf
.4932 0 TD
[(ev)-219.8(T,)-209.3(Hadna)]TJ
/F16 1 Tf
4.8181 0 TD
(C)Tj
/F10 1 Tf
.5008 0 TD
[(ev)-212.3(M,)-215(et)-209.9(al.)-218(Bread)-213.8(supplement)-11.9(ation)]TJ
-15.9718 -1.1988 TD
[(with)-269.8(hemp)-269.4(seed)-273.8(cake:)-268.8(a)-272.2(by-product)-272.7(of)-268.2(hemp)-269.4(oil)-275.7(processing.)-270.4(J)-273.4(Food)-267.1(Qual.)]TJ
T*
[(2015;38:4314)-15.5(40.)]TJ
-1.7224 -1.1988 TD
[(76.)-505.4(Korus)-308.1(J,)-304(Witczak)-305.7(M,)-298.5(Ziobro)-310.8(R,)-296.3(et)-301(al.)-309(Hemp)-297.8(\()]TJ
/F13 1 Tf
19.591 0 TD
[(Cannab)-12.8(is)-298.2(sativa)]TJ
/F10 1 Tf
6.7529 0 TD
[(subs)-11.5(p.)-295.7(sativa\))]TJ
-24.6216 -1.1988 TD
[(our)-299.2(and)-296.3(protein)-303(preparation)-304.8(as)-294.5(natural)-300.8(nutrients)-301.7(and)-296.3(structure)-309.5(forming)]TJ
0 -1.2064 TD
[(agents)-303.4(in)-304(starch)-305.6(based)-301.9(glut)-10.1(en-free)-303.3(bread.)-306.9(LWT)-301.8(2017;84:143150.)]TJ
-1.7224 -1.1988 TD
[(77.)-505.4(Rado)]TJ
/F14 1 Tf
3.8165 .0304 TD
()Tj
/F15 1 Tf
.0228 -.0304 TD
(c)Tj
/F10 1 Tf
.4477 0 TD
[(aj)-306.3(O,)-299.7(Dimic)]TJ
4.2414 .0304 TD
()Tj
.6677 -.0304 TD
[(E,)-300.4(Tsao)-304(R.)-303.9(Effects)-300.1(of)-306.1(hemp)-299.7(\()]TJ
/F13 1 Tf
11.4344 0 TD
[(Cannabis)-303.4(sativa)]TJ
/F10 1 Tf
6.7453 0 TD
[(L.\))-306(seed)-304.1(oil)]TJ
-25.6535 -1.1988 TD
[(press-ca)-12.5(ke)-299.1(and)-303.9(decaffeinated)-310.7(green)-298(tea)-307.6(leaves)-301.3(\()]TJ
/F13 1 Tf
20.0994 0 TD
[(Camellia)-306.4(sin)-10(ensis)]TJ
/F10 1 Tf
6.8515 0 TD
.2957 Tc
[(\)o)295.7(n)]TJ
-26.9509 -1.1988 TD
0 Tc
[(functional)-308.9(characteri)-13.6(stics)-298.6(of)-306.1(gluten-free)-305.8(crackers.)-315.5(J)-296.1(Food)-305.1(Sci.)-307.3(2014;79:)]TJ
T*
[(C318C3)-11.2(25.)]TJ
-1.7224 -1.1988 TD
[(78.)-505.4(Oomah)-307.3(BD,)-305.6(Busson)-305.3(M,)-298.5(Godfrey)-305.5(DV,)-309.8(et)-301(al.)-301.4(Characteristics)-316.2(of)-298.6(hemp)]TJ
1.7224 -1.2064 TD
(\()Tj
/F13 1 Tf
.2807 0 TD
[(Cannabis)-311(sativa)]TJ
/F10 1 Tf
6.7529 0 TD
[(L.\))-306(seed)-304.1(oil.)-298.8(Food)-305.1(Chem.)-305.2(2002;76:3343)-15.5(.)]TJ
-8.756 -1.1988 TD
[(79.)-505.4(Da)-291.5(Por)-9.7(to)-290.3(C,)-293.3(Decort)-11.9(i)-287(D)0(,)-292.7(Natol)-11.4(ino)-294.2(A.)-291.6(Potential)-301.3(oil)-290.9(yield,)-296.2(fatty)-295.7(acid)-293.7(compo)-12.4(si-)]TJ
1.7224 -1.1988 TD
[(tion,)-207.7(and)-205.3(oxidation)-207.1(stability)-209.8(of)-199.9(the)-204.2(hempseed)-209.3(oil)-199.9(from)-205.8(four)]TJ
/F13 1 Tf
23.9311 0 TD
[(Cannabis)-204.8(sativa)]TJ
/F10 1 Tf
-23.9311 -1.1988 TD
[(L.)-306.2(cultivars.)-305.6(J)-303.7(Diet)-303.7(Suppl.)-303.3(2015;12:1)-12.8(10.)]TJ
-1.7224 -1.1988 TD
[(80.)-505.4(Bouloc)-308.9(P.)-303.9(Hemp:)-305.7(industrial)-305.7(production)-313(and)-296.3(uses.)-309(CAB)-301.3(Interna)-10.8(tional:)-304(New)]TJ
1.7224 -1.1988 TD
[(Delhi,)-307.9(India,)-301.5(2013.)]TJ
-1.7224 -1.2064 TD
[(81.)-505.4(Sergeant)-305.5(S,)-308(Rahbar)-299.8(E,)-300.4(Chilton)-311.2(FH.)-302.8(Gamma-linolenic)-311.5(acid,)-301.6(dihommo-)]TJ
1.7224 -1.1988 TD
[(gamma)-306.8(linolenic,)-308.9(eicosanoids)-304.8(and)-303.9(inammatory)-310.1(processes.)-313.8(Eur)-302.1(J)-303.7(Phar-)]TJ
T*
[(macol.)-309.1(2016;785:7786.)]TJ
-1.7224 -1.1988 TD
[(82.)-505.4(Dimic)]TJ
3.7558 .0303 TD
()Tj
.5691 -.0303 TD
[(E,)-209.3(Romanic)]TJ
4.1504 .0303 TD
()Tj
.5691 -.0303 TD
[(R,)-212.9(Vujasinovic)]TJ
5.2658 .0303 TD
()Tj
.5767 -.0303 TD
[(V.)-207(Essential)-211.5(fatty)-212.2(acids,)-210.1(nutritive)-214.4(value)-215.2(and)]TJ
-13.1644 -1.1988 TD
[(oxidative)-268(stability)-262.9(of)-260.6(cold)-262.1(press)-11.3(ed)-258.2(hempseed)-262.5(\()]TJ
/F13 1 Tf
19.151 0 TD
[(Cannabis)-273.1(sativa)]TJ
/F10 1 Tf
6.6694 0 TD
[(L.\))-260.4(oil)-260.6(fr)-9.2(om)]TJ
-25.8204 -1.1988 TD
[(different)-308.3(varieties.)-308.8(Acta)-302.9(Aliment.)-305.1(2009;38:)-13.6(229236.)]TJ
-1.7224 -1.1988 TD
[(83.)-505.4(Smerigl)-10.1(io)-254.3(A,)-261.3(Galati)-265.1(EM,)-264.8(Monforte)-271.9(MT,)-257.2(et)-263(al.)-263.5(Polyphenolic)-271.9(compounds)-269.1(and)]TJ
1.7224 -1.2064 TD
[(antioxida)-11.2(nt)-302.1(activity)-302.9(of)-306.1(cold-pressed)-305.5(see)-8.7(d)-295.4(oil)-306.1(from)-304.5(nola)-304.3(cultivar)-305.8(of)]TJ
/F13 1 Tf
28.0436 0 TD
(Can-)Tj
-28.0436 -1.1988 TD
[(nabis)-305.4(sativa)]TJ
/F10 1 Tf
5.1444 0 TD
[(L.)-306.2(Phytother)-306.1(Res.)-304.3(2016;30:1298)-14.7(1307.)]TJ
-6.8667 -1.1988 TD
[(84.)-505.4(Leizer)-308.3(C,)-300.9(Ribnicky)-307.9(D,)-300.3(Poulev)-305.1(A,)-299.2(et)-301(al.)-309(The)-295.2(compo)-12.4(sition)-304.2(of)-298.6(hemp)-307.3(seed)-304.1(oil)]TJ
1.7224 -1.1988 TD
[(and)-303.9(its)-306(potential)-300.7(as)-302.1(an)-304.4(important)-307.2(source)-311.8(of)-298.6(nutrition.)-313.1(J)-296.1(Nutraceut)-308.8(Funct)]TJ
T*
[(Med)-306.1(Foods)-304.6(2000;2:3553.)]TJ
-1.7224 -1.1988 TD
[(85.)-505.4(Mattha)]TJ
4.3021 .0076 TD
()Tj
.3794 -.0076 TD
[(us)-308.4(B,)-301.5(Bru)]TJ
3.2702 0 TD
[()-126.3(h)0(l)-304(L)0(.)-298.6(Virgin)-303.2(hemp)-307.3(seed)-304.1(oil:)-298.8(an)-304.4(interesting)-305.3(ni)-8.1(che)-299.3(product.)]TJ
-6.2294 -1.2064 TD
[(Eur)-302.1(J)-303.7(Lipid)-302.2(Sci)-307(Technol.)-302(2008;110)-11.7(:655661.)]TJ
-1.7224 -1.1988 TD
[(86.)-505.4(Estruch)-308.5(R,)-303.9(Ros)-300.9(E,)-300.4(Salas-Sal)-11.4(vado)]TJ
14.1128 .0304 TD
()Tj
.7132 -.0304 TD
[(J,)-304(et)-301(al.)-301.4(Primary)-306.3(prevent)-10.6(ion)-301.8(of)-298.6(cardiova)-13.1(s-)]TJ
-13.1037 -1.1988 TD
[(cular)-303.8(disease)-308.9(with)-300.1(a)-302.5(mediterranean)-312.8(diet)-299.1(supple)-10.9(mented)-304.8(with)-300.1(extra-virgin)]TJ
T*
[(olive)-305.9(oil)-298.5(or)-305.5(nuts.)-307.3(N)-300(Engl)-302.6(J)-296.1(Med)-306.1(2018;378:e34.)]TJ
31.8829 50.404 TD
[(87.)-505.4(Kaul)-243.5(N,)-247.2(Kreml)-245.9(R,)-243.2(Austria)-249.3(JA,)-246.3(et)-240.3(al.)-248.3(A)-245.8(comparison)-251.1(of)-245.4(sh)-240.2(oil,)-245.7(axseed)-250.9(oil)-245.4(and)]TJ
1.7224 -1.2064 TD
[(hempseed)-239.7(oil)-237.8(supplement)-11.9(ation)-236.8(on)-242.4(selected)-240.2(para)-9.4(meters)-239(of)-237.9(cardiovas)-12.6(cular)]TJ
0 -1.1988 TD
[(health)-302.4(in)-296.4(healthy)-304.9(volun)-10.2(teers.)-305.9(J)-296.1(A)0(m)-300.6(Coll)-303.2(Nu)-9.4(tr.)-297.1(2008;27)-13.3(:5158.)]TJ
-1.7224 -1.1988 TD
[(88.)-505.4(De)25.4(l)-294.5(B)0(o)-283.8(C)0(,)-278.1(D)0(e)17.8(o)0(n)-280.4(V)0(,)-282.9(Abe)27.1(ll)17.9(o)-293.6(F)0(,)-280(e)0(t)-278.2(a)0(l)17.5(.)-296.2(Ei)19.9(gh)19(t-)17(we)22.6(ek)-284(he)20.1(mps)29.6(eed)-274.2(oi)18.8(l)-294.5(i)0(n)22.2(t)0(e)17.7(r)0(v)19.5(e)0(n)20.1(tio)22.1(n)]TJ
1.7224 -1.1988 TD
[(i)16.5(mpr)24.9(ov)18.4(es)-243.1(th)16.6(e)-251.2(f)0(a)18.8(t)0(t)21.8(y)-252.8(ac)15.5(id)-240.9(co)16.8(mp)21.6(os)17.9(iti)21.2(on)-234.8(of)-245.4(er)17.7(yt)16.1(hr)16.6(oc)16.8(yt)23.6(e)-251.2(pho)23.7(sp)16.1(ho)23.1(li)17.9(pi)17.1(ds)-241.8(an)21.9(d)-257.5(t)0(h)24.2(e)]TJ
T*
[(om)23.4(eg)20.1(a-3)-272.1(ind)22.7(ex)17.1(,)-288.6(b)0(u)18(t)-292.6(do)18(es)-281.1(no)15.6(t)-285(a)0(f)18.8(f)0(e)17.1(c)0(t)-285.7(t)0(h)16.6(e)-289.1(li)17.9(pi)17.1(d)-287.8(p)0(r)19(o)0()13.9(l)0(e)-280.2(i)0(n)-281.3(c)0(h)20.2(i)0(l)17.9(d)0(r)19(e)0(n)-283.4(a)0(n)21.9(d)-295.4(ad)24.3(o-)]TJ
T*
[(l)16.5(e)0(s)14.8(c)0(e)21.3(n)0(t)16.6(s)-295.5(wi)24.7(th)-286.9(pr)19(im)14.9(a)16.2(r)0(y)-287.4(h)0(y)18.4(p)0(e)22.5(rli)21.2(p)15.7(i)0(d)17.1(e)0(m)20.3(i)0(a)17.5(.)-296.2(Fo)18.4(od)-278(Res)-273.6(Int)25.5(.)-288.6(2)0(0)18.4(1)0(9)18.4(;)0(1)16.5(1)0(9)18.4(:)0(4)16.5(6)0(9)18.4()0(4)16(7)0(6)18.4(.)]TJ
-1.7224 -1.2064 TD
[(89.)-505.4(Sc)17.9(hw)21.4(ab)-279.2(US)18.6(,)-296.2(C)0(.)-278.1(Cal)20.4(l)16.5(a)0(w)16.7(a)0(y)-282.2(J)0(,)-281.2(E)0(r)14.3(k)0(k)17.9(i)0(l)17.9(a)]TJ
14.8564 .0152 TD
()Tj
.6753 -.0152 TD
[(AT)15.5(,)-288.6(e)0(t)-285.8(a)0(l)25.1(.)-296.2(Ef)21.2(fe)17.1(ct)17.8(s)-295.5(o)0(f)-275.8(hem)26(ps)16.1(ee)21.2(d)-295.4(a)0(n)21.8(d)]TJ
-13.8093 -1.1988 TD
[(a)20.2(xs)18.4(ee)21.2(d)-295.4(o)0(i)18.8(l)0(s)-278.9(o)0(n)-280.4(t)0(h)16.6(e)-289.1(pr)19(o)13.9(le)-280.1(of)-283.4(se)22.4(rum)-276.8(li)17.9(pi)17.1(ds)16.1(,)-288.6(s)0(e)22.4(rum)-276.8(to)20.8(tal)-275.1(an)21.9(d)-295.4(l)0(i)17.9(p)0(o)18(p)0(r)19(o)0(t)20.8(e)0(i)15.7(n)]TJ
T*
.0203 Tc
[(l)6.5(i)-1.1(pi)6.5(d)-305.4(c)4.5(onc)4.5(e)-3.2(ntrations)-297.9(a)-1.5(nd)-305.4(hae)4.4(m)-4.1(o)7.4(s)-2(tatic)-299(f).2(ac)4.5(tors.)-298.7(E).9(ur)-302.6(J)-298.6(N)1(utr.)-306.2(2)6.8(006;)4.9(45:)]TJ
T*
.0215 Tc
[(4)8(704)8(77.)]TJ
-1.7224 -1.1988 TD
0 Tc
[(90.)-505.4(F)16.2(ras)19.9(s)15.6(ine)21.5(tt)21.8(i)-226.3(S)0(,)-216.9(M)0(o)15.2(c)0(c)21.4(i)0(a)-217.7(E)0(,)-216.9(C)0(a)19.1(lta)28.4(vu)18.4(tur)24.1(o)-225.3(L)0(,)-222.8(e)0(t)-217.5(a)0(l)25.1(.)-227.9(Nut)24.2(ra)19.5(ceu)23.6(ti)19.9(ca)15.5(l)-218.7(pot)21.3(en)20.1(ti)19.9(al)-217.7(of)-215.1(he)20.1(mp)]TJ
1.7224 -1.1988 TD
(\()Tj
/F13 1 Tf
.2656 0 TD
[(Ca)17.3(nn)14.9(ab)15.7(is)-275.4(sat)19.9(iv)20.1(a)]TJ
/F10 1 Tf
6.6163 0 TD
[(L.)20(\))-288.1(s)0(e)14.8(e)0(d)14.9(s)-287.9(an)21.8(d)-295.4(s)0(p)16.1(r)0(o)20.8(uts)28.8(.)-296.2(F)0(o)18.4(o)0(d)-277.9(C)0(h)16.2(e)0(m)20.3(.)-296.2(20)18.4(18)18.4(;2)16.5(62)18.4(:5)16.5(6)23.6(66)18.4(.)]TJ
-8.6043 -1.1988 TD
[(91.)-505.4(The)-295.2(Eu)-9.5(ropean)-299.1(Industri)-12.1(al)-301.2(Hemp)-305.4(Association.)-304.5(Re)-8.5(asonable)-299.7(regul)-10.9(ation)-297.5(of)]TJ
1.7224 -1.2064 TD
[(cannabidiol)-306.3(\(CBD\))-301.9(in)-304(food,)-303.7(cosmetics,)-314.9(as)-302.1(herbal)-300(natural)-308.4(medicine)-306.1(and)-303.9(as)]TJ
0 -1.1988 TD
[(medicinal)-303(product.)-307.5(EIHA:)-309.6(Hu)]TJ
11.4117 0 TD
[()-118.7(rth,)-306.6(Germany,)-306.2(2018.)]TJ
-13.134 -1.1988 TD
[(92.)-505.4(Citti)-298.8(C,)-308.4(Pacchetti)-306.3(B,)-301.5(Vandelli)-302.5(MA,)-301.5(et)-301(al.)-309(Analysis)-306.3(of)-298.6(cannab)-9.6(inoids)-299.5(in)-304(com-)]TJ
1.7224 -1.1988 TD
[(mercial)-299.6(hemp)-307.3(seed)-304.1(oil)-298.5(and)-303.9(decarboxyla)-14(tion)-298.4(kinetics)-310.4(studies)-303.5(of)-306.2(cannabi-)]TJ
T*
[(diolic)-304.9(acid)-301.3(\(CBDA\).)-305.2(J)-303.7(Pharm)-302.9(Biomed)-307.1(Anal.)-298.8(2018;149)-11.7(:532540.)]TJ
/F4 1 Tf
-.7891 -5.4706 TD
[(Cite)-301.7(this)-306(article)-307(as:)]TJ
/F10 1 Tf
8.5739 0 TD
[(Cerino)-303.9(P,)-296.3(Buon)-10.3(erba)-299.5(C,)-300.9(Cannazz)-9.9(a)-302.5(G)0(,)-296.2(DAuria)-310.6(J,)]TJ
-8.5739 -1.1988 TD
[(Ottoni)-306.2(E,)-300.4(Fulgione)-307.4(A,)-299.2(Di)-298.7(Stasio)-306.9(A,)-306.8(Pierri)-302.7(B,)-301.5(Gallo)-305.1(A)-298.9(\(2021\))-304.1(A)-306.5(review)-298.8(of)]TJ
7.4718 0 0 7.4718 317.8204 480.0754 Tm
[(hemp)-239(as)-233.8(food)-242.7(and)-235.6(nutritional)-242.2(supplement)-11.9(,)]TJ
/F13 1 Tf
17.8004 0 TD
[(Cannabis)-242.7(and)-234.9(Cannabinoid)]TJ
-17.8004 -1.1988 TD
(Research)Tj
/F10 1 Tf
3.8621 0 TD
[(6:1,)-308.4(1927,)-305.7(DOI:)-302.4(10.1089/can.2)-14.5(020.0001.)]TJ
/F4 1 Tf
8.9663 0 0 8.9663 390.8976 416.6361 Tm
[(Abbreviations)-336.5(Used)]TJ
/F10 1 Tf
7.4718 0 0 7.4718 334.4314 404.3337 Tm
(CBC)Tj
/F8 1 Tf
1.8514 0 TD
()Tj
/F10 1 Tf
.9409 0 TD
[(cannabichro)-12.8(mene)]TJ
-2.8757 -1.2064 TD
(CBD)Tj
/F8 1 Tf
1.9348 0 TD
()Tj
/F10 1 Tf
.9409 0 TD
(cannabidiol)Tj
-2.8681 -1.1988 TD
(CBG)Tj
/F8 1 Tf
1.9272 0 TD
()Tj
/F10 1 Tf
.9409 0 TD
(cannabigerol)Tj
-2.8605 -1.1988 TD
(DEA)Tj
/F8 1 Tf
1.9197 0 TD
()Tj
/F10 1 Tf
.9409 0 TD
[(Drug)-334.3(Enforcement)-349.4(Administration)]TJ
-2.8453 -1.1988 TD
(FDA)Tj
/F8 1 Tf
1.9045 0 TD
()Tj
/F10 1 Tf
.9409 0 TD
[(Food)-335.4(and)-334.3(Drug)-341.9(Administration)]TJ
-3.1792 -1.1988 TD
(IZSM)Tj
/F8 1 Tf
2.2383 0 TD
()Tj
/F10 1 Tf
.9409 0 TD
[(The)-333.2(Zoo-prophylac)-17.7(tic)-329.8(Insti)-10.6(tute)-333.3(of)-336.5(Southern)-339.1(Italy)]TJ
-2.815 -1.1988 TD
(THC)Tj
/F8 1 Tf
1.8741 0 TD
()Tj
/F10 1 Tf
.9409 0 TD
[(tetrahydrocannabino)-18.8(l)]TJ
-3.7786 -1.2064 TD
(TRPA1)Tj
/F8 1 Tf
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